Figures & data
TABLE 1. Methods of Dosing Rodent Lower Respiratory Tract with Particles
TABLE 2. Physicochemical Characteristics which influence Toxicity of CNTs and CNFs
FIGURE 1 a. MWCNT aerosols at a research facility.
![FIGURE 1 a. MWCNT aerosols at a research facility.](/cms/asset/e6e4185c-702f-428b-81fe-45d9f44cf02e/uteb_a_1051611_f0001_b.gif)
FIGURE 1 b. MWCNT aerosols collected at a research facility.
![FIGURE 1 b. MWCNT aerosols collected at a research facility.](/cms/asset/7dd4b7da-c8f7-48c0-b6b6-b10ad531560c/uteb_a_1051611_f0002_b.gif)
FIGURE 2. CNF aerosols collected on impactor stages during thermal treatment.
![FIGURE 2. CNF aerosols collected on impactor stages during thermal treatment.](/cms/asset/0915d7f5-74b3-4e4a-b3be-b90a27103591/uteb_a_1051611_f0003_b.gif)
FIGURE 3. Dosimetric Extrapolation of Inhaled Particles from Rats to Humans.
![FIGURE 3. Dosimetric Extrapolation of Inhaled Particles from Rats to Humans.](/cms/asset/f1a9ef93-29d4-45e2-bd52-5f63fd47d664/uteb_a_1051611_f0004_oc.jpg)
FIGURE 4. Exposure-Response and Dose-Response.
![](/cms/asset/0b7e78fc-c2b4-41bc-ba6e-ee83c4f122df/uteb_a_1051611_ilg0002.jpg)
![](/cms/asset/8d0e8e0c-664d-41d7-86d4-6f79892cc20e/uteb_a_1051611_ilg0003.jpg)
![](/cms/asset/96be608a-e07b-45b2-bcb8-4ac950033dc3/uteb_a_1051611_ilg0004.jpg)
![](/cms/asset/d4604dce-8bfb-475d-99a5-f95b821d630f/uteb_a_1051611_ilg0005.jpg)
![](/cms/asset/f0223184-22ec-4f2e-8f17-b088a70f32c4/uteb_a_1051611_ilg0006.jpg)
![FIGURE 4. Exposure-Response and Dose-Response.](/cms/asset/1e6894eb-4c95-4d18-834e-7cae67ec61e7/uteb_a_1051611_f0005_oc.jpg)
FIGURE 5. MWCNT aerosol size distribution in rodent inhalation study.
![FIGURE 5. MWCNT aerosol size distribution in rodent inhalation study.](/cms/asset/84ace7bc-fd02-4fed-910e-995a73a47e66/uteb_a_1051611_f0006_oc.jpg)
FIGURE 6. MWCNT aerosols collected in rodent inhalation study.
![FIGURE 6. MWCNT aerosols collected in rodent inhalation study.](/cms/asset/474d6bab-ca9b-41d9-8252-d1311c4ef0dc/uteb_a_1051611_f0007_b.gif)
FIGURE 7. MWCNT aerosols collected in rodent inhalation study.
![FIGURE 7. MWCNT aerosols collected in rodent inhalation study.](/cms/asset/f486c92e-f97c-4b74-a595-c92104e846e0/uteb_a_1051611_f0008_b.gif)
TABLE 3. 90-Day Rat Inhalation Studies with MWCNT and CNF, Exposure-Dose-Response Comparison
TABLE 4. Surface Areas of Respiratory Tract Regions at FRC
TABLE 5. Acute to Chronic Inhalation Exposures of Rodents to CNT/CNF for Toxicity Testing. (rat as preferred species; 4–6 hrs/day, 5 d/wk; whole-body)
TABLE 6. Percent Deposition of Inhaled Particles of Unit Density (ρ = 1 g/cm3) in Extrathoracic, Tracheobronchial, and Alveolar Regions of Rodents
FIGURE 9. MWCNT aerosol size distribution in rodent inhalation study.
![FIGURE 9. MWCNT aerosol size distribution in rodent inhalation study.](/cms/asset/c20d081f-2013-4a66-a715-a0cd9c4b9c70/uteb_a_1051611_f0010_oc.jpg)
FIGURE B-1. CNT/CNF thoracic fractions for humans and rats.
![FIGURE B-1. CNT/CNF thoracic fractions for humans and rats.](/cms/asset/54245b58-73ed-41b3-a81d-2861ac42a54a/uteb_a_1051611_f0011_oc.jpg)
TABLE 7. Instruments and techniques for characterizing nano-aerosol exposure (modified from ISO TR12885)
TABLE 8. Recommendation for exposure characterization of sampled and airborne CNT/CNF (modified from Oberdörster et al., 2005)
FIGURE A-1. CNT/CNF inhalability for humans and rats.
![FIGURE A-1. CNT/CNF inhalability for humans and rats.](/cms/asset/67043415-e5b5-4ed2-9862-c8eb04556009/uteb_a_1051611_f0012_oc.jpg)
FIGURE B-2. Human to rat ratios for equal thoracic fractions.
![FIGURE B-2. Human to rat ratios for equal thoracic fractions.](/cms/asset/7c288e1e-af6f-4b61-bcea-09485809e8a3/uteb_a_1051611_f0013_oc.jpg)
FIGURE B-3. CNT/CNF respiratory fractions for humans at different aspect ratios.
![FIGURE B-3. CNT/CNF respiratory fractions for humans at different aspect ratios.](/cms/asset/ffb990cf-f644-4a39-b11e-c17f80881b19/uteb_a_1051611_f0014_oc.jpg)
FIGURE B-4. HEC/CR ratios for CNT/CNF (100 nm—2 μm diameter) at aspect ratio of 10.
![FIGURE B-4. HEC/CR ratios for CNT/CNF (100 nm—2 μm diameter) at aspect ratio of 10.](/cms/asset/6a7bade6-170a-4372-a549-3b7fb13908e4/uteb_a_1051611_f0015_oc.jpg)