Evaluation of copeptin and psychological stress among healthcare providers during COVID-19 pandemic

Figures & data

Figure 1. Study flow chart

Table 1. Baseline clinical characteristics and metabolic variables of studied groups

	Quarantine study group (n = 65)	Control group (n = 40)	P value
BMI (kg/m^2)	24.28 ± 2.54	26.23 ± 2.27	0.231
Systolic BP (mmHg)	137 ± 9.3	136.7 ± 8.4	0.145
Diastolic BP (mmHg)	82.5 ± 6.4	79.5 ± 7.3	0.168
Heart rate beats/min	72 ± 4	68 ± 5	0.098
FBG (mmol/L)	4.88 ±0.75	4.86 ±0.71	0.425
S. sodium (mmol/L)	140.4 ± 5.23	138.78 ± 4.95	0.311
Plasma copeptin (pmol/l)	15.76 ± 8.6	4.18 ± 1.54	0.001*
S. cortisol (nmol/L)	501.7 (348.4–675.4)	488 (332.62–612.23)	0.097
S. insulin (pmol/L)	85.75 ± 21.82	80.14 ± 20.75	0.042*

Data are means ± SE or n (%). *P < 0.05.

Table 2. Studied parameters for quarantine HCP study group at the three measurements

	Pre-quarantine (Baseline)	At end of first week	Post-quarantine
Plasma copeptin (pmol/L)	15.76 ± 8.6	8.45 ± 3.54	3.98 ± 1.28
P1 P2		0.003*	0.001* 0.001*
S. cortisol (nmol/L)	501.7 (348.4–675.4)	474.7 (262–628.6)	468(298–587.5)
P1 P2		0.125	0.098 0.13
S. insulin (pmol/L)	85.75 ± 21.82	83.65 ± 20.93	77.34 ± 23.98
P1 P2		0.236	0.042* 0.047*
Systolic BP(mmHg)	136.9 ± 8.9	149.0 ± 12.3	139.9 ± 10.9
P1 P2		0.041*	0.465 0.045*
Diastolic BP(mmHg)	82.5 ± 9.1	90.2 ± 8.25	87.8 ± 8.9
P1 P2		0.062	0.082 0.123

Data are means ± SE. *P < 0.05.

P1 comparison between pre-quarantine and both at end of first week and post-quarantine.

P2 comparison between at end of first week and post-quarantine.

Table 3. Comparison between stress score pre- and post-quarantine period of HCP

	Pre-quarantine period		Post-quarantine period
	No.	%	No.	%
PSS score low stress	8	12.3	29	44.6
Moderate stress	24	36.9	27	41.5
High stress	33	50.8	9	13.8
Range Mean S.D.	31.0–72.0 66.9 18.3		16.0–42.0 23.0 7.95
T test P value	5.98 0.001*

Data are means ± SE. *P < 0.05.

The following 3 categories: low stress (PSS score <20), moderate stress (PSS score 20–40), and high stress (PSS score >40)

Table 4. Correlation of copeptin with PSS, blood pressure, cortisol, and insulin

Plasma copeptin	Correlation coefficient	P value
PSS score	0.465	0.0036*
Systolic blood pressure	0.353	0.012*
Diastolic blood pressure	0.153	0.107
Cortisol	0.089	0.562
Insulin	0.336	0.013*