Goal-directed fluid therapy versus restrictive fluid therapy: A cardiomerty study during one-lung ventilation in patients undergoing thoracic surgery

Figures & data

Figure 1. Study design

Figure 2. Fluid flow chart of the intraoperative period in both groups

Table 1. Intraoperative and postoperative urine output (ml/h)

Urine output (ml/h)	^∙GDT Median (Min. – Max.)	^∙∙RT Median (Min. – Max.)	U	p
Intra-operative period
1st hour	50.0 (50.0–100.0)	50.0 (25.0–100.0)	287.0	0.562
2nd hour	50.0 (50.0–100.0)	50. (25.0–100.0)	230.0	0.074
3rd hour	50.0 (50.0–100.0)	50.0 (25.0–50.0)	140.00	<0.001*
4th hour	50.0 (50.0–50.0)	50.0 (50.0–50.0)	24.50	1.000
Postoperative period
0 hour	50.0 (50.0–100.0)	50.0 (50.0–100.0)	175.00*	<0.001*
6 hours	300.0 (200.0–400.0)	250.0 (150.0–300.0)	100.00*	<0.001*
12 hours	350.0 (250.0–450.0)	350.0 (100.0–450.0)	302.5	0.839
24 hours	600.0 (450.0–800.0)	600.0 (300.0–750.0)	256.5	0.269

U: Mann–Whitney test.

p: p value for comparing between the two groups.

*: Statistically significant at p ≤ 0.05.

Data was expressed by using Median (Min. – Max.)

^∙GDT: Goal-directed therapy.

^∙∙RT: Restrictive therapy.

Figure 3. Comparison between the two studied groups according to serum lactate (mmol/l)

Figure 4. Comparison between the two studied groups according to postoperative serum creatinine (mg/dL)

Figure 5. Comparison between the two studied groups according to bicarbonate level in arterial blood gases (mEq/L)

Figure 6. Comparison between the two studied groups according to central venous oxygen saturation (ScVO₂) (%)

Table 2. Intraoperative blood loss, fluids and blood products transfused in both groups

	Mean ± SD.		P value
	^∙GDT	^∙∙RT
Total amount of blood losses (ml)	568.0 ± 172.5	580.0 ± 197.9	0.906
Total amount of packed red blood cells received (ml)	333.3 ± 125.0	400.0 ± 129.1	0.258
Total amount of fresh frozen plasma received (ml)	285.71 ± 106.9	306.7 ± 103.3	0.655
Amount of crystalloid (ml)	1720.0 ± 291.5	912.0 ± 104.4	<0.001*
Amount of colloid (ml)	125.0 ± 27.39	130.0 ± 31.62	0.739
Total amount of noradrenaline	19.21 ± 6.83	28.14 ± 6.32	0.040*
Number of patients who received noradrenaline	3(12.0%)	16(64.0%)	<0.001*

p: p value for comparing between the two groups.

*: Statistically significant at p ≤ 0.05.

^∙GDT: Goal-directed therapy.

^∙∙RT: Restrictive therapy.

Figure 7. Comparison between the thoracic fluid content (TFC) (k.ohm⁻¹) in the goal-directed therapy group (GDT) at different times of one lung ventilation

Figure 8. Comparison between the two studied groups according to Serum Neutrophil gelatinase-associated lipocalin (Ngal) (ng/ml)