Nitroglycerin versus labetalol to control the blood pressure in acute severe pre-eclampsia

Figures & data

Figure 1. CONSORT flow diagram.

Table 1. Patients’ characteristics.

Variables	Group N (n = 100)	Group L (n = 100)	P- value
Age (years)	27.68 ± 2.84	28.26 ± 3.24	0.179
Parity (MP/PG)	66/34	74/26	0.28
BMI (Kg/m^2)	26.2 ± 2.2	26.52 ± 2.44	0. 593
Gestational age (month)	38.1 ± 0.6	38.13 ± 0.72	0.289

Data are presented as mean ± SD, number of patients. P-value < 0.05 is considered statistically significant. MP: multipara, PG: primigravida

Table 2. Blood pressure parameters.

Variables	Group N (n = 100)	Group L (n = 100)	P- value
SBP (mmHg)
At 0 minutes	169.3 ± 3.14	168.4 ± 2.75	0.057
At 30 minutes	152.6 ± 6.11	159.3 ± 3.4	<0.001*
	0.001†	<0.001†
At 60 minutes	141.7 ± 7.8	144.8 ± 6.4	0.002*
	<0.001 †	<0.001 †
At 90 minutes	135.2 ± 8.6	139.25 ± 6.9	<0.001*
	<0.001 †	<0.001 †
DBP (mmHg)
At 0 minutes	124.5 ± 4.23	123.7 ± 3.9	0.192
At 30 minutes	108.4 ± 6.3	113.7 ± 4.3	<0.001*
	<0.001 †	<0.001 †
At 60 minutes	94.5 ± 9.4	98.62 ± 8	<0.001*
	<0.001 †	<0.001 †
At 90 minutes	87.7 ± 9.5	90.64 ± 8.16	0.022*
	<0.001 †	<0.001 †
Time to control BP (minutes)	60.5 ± 8.6	72.89 ± 10.8	<0.001*
Attacks of hypotension (n)	15	12	0.68
Severe persistent hypertension	4	13	0.04*

Data are presented as mean ± SD, number of patients. *p-value <0.05 is considered statistically significant between the 2 groups. †p-value <0.05 is considered statistically significant compared to the baseline values in same group.

Table 3. Maternal side effects.

Variables	Group N (n = 100)	Group L (n = 100)	P value
Tachycardia (n)	21	4	˂0.001*
Bradycardia (n)	0	7	0.014*
Headache (n)	13	4	0.04*
N& V (n)	2	0	1
Flushes (n)	6	0	0.029*
Dizziness (n)	5	6	1

Values are expressed as number, *p < 0.05 is considered statistically significant.

Table 4. Fetal side effects.

Variables	Group N (n = 100)	Group L (n = 100)	P value
Time to delivery (hour)	6.34 ± 0.26	6.25 ± 0.26	0.057
Fetal distress (n)	4	3	0.621
Still births (n)	4	5	1
Apgar score 1 min (˂7)	2	1	1
Apgar score 5 min (˂7)	2	1	1
Birth weight (Kg)	2.76 ± 0.25	2.72 ± 0.2	0.185

Data are presented as mean ± SD, number of patients. *p < 0.05 is considered statistically significant.