Assessment of Analgesic Effect of Ketamine Vs Ketamine Magnesium Infusion and Their Effect on Postoperative Morphine Consumption after Surgical Nephrectomy

Figures & data

Table 1. Basal Features of included participants.

	Group I (N = 50)	Group II (N = 50)	P. Value
Age (Years)	52.32 ± 9.86	53.62 ± 8.72	0.49
Sex
Male	35 (70%)	31 (62%)	0.398
Female	15 (30%)	19 (38%)
BMI (Kg/m^2)	25.6 ± 2.3	24.9 ± 3.1	0.2
Operation type
Partial nephrectomy	28 (56%)	26 (52%)	0.69
Radical	22 (44%)	24 (48%)
nephrectomy
ASA physical Status
I II	37 (74%) 13 (26%)	35 (70%) 15 (30%)	0.66
Duration of surgery (Min)	89.56 ± 12.6	92.26 ± 8.89	0.21

Table 2. Mean Arterial blood Pressure (MAP) variations among the two studied collections postoperatively.

	Group I (N = 50)	Group II (N = 50)	P. Value
30 min.	86.02 ± 2.62	85.6 ± 2.34	0.4001
1 hr	83.8 ± 2.47	83.28 ± 2.59	0.3069
2 hr	80.8 ± 2.05	72.8 ± 2.05	< 0.001
4 hr	84.68 ± 2.23	76.28 ± 1.82	< 0.001
6 hr	85.52 ± 2.33	77.04 ± 1.94	< 0.001
8 hr	87.58 ± 3.55	86.66 ± 1.56	0.0963
10 hr	87.6 ± 1.03	78.6 ± 1.03	< 0.001
12 hr	89.12 ± 2.36	80.14 ± 2.33	< 0.001
16 hr	88.3 ± 1.57	79.32 ± 1.53	< 0.001
18 hr	86.88 ± 1.83	78.16 ± 1.52	< 0.001
24 hr	86.02 ± 1.82	77.46 ± 1.43	< 0.001
36 hr	84.06 ± 1.6	75.86 ± 1.32	< 0.001
48 hr	83.58 ± 1.79	75.36 ± 1.47	< 0.001

Table 3. Heart rate changes postoperatively between the two studied groups.

	Group I (N = 50)	Group II (N = 50)	P. Value
30 min.	116.1 ± 10.36	115.78 ± 9.66	0.8734
1 hr	104.06 ± 9.72	95.8 ± 8.86	< 0.001
2 hr	90.7 ± 7.76	83.48 ± 7.14	< 0.001
4 hr	86.36 ± 7.7	79.48 ± 7.03	< 0.001
6 hr	99.64 ± 9.02	91.74 ± 8.35	< 0.001
8 hr	103.62 ± 6.99	95.38 ± 6.48	< 0.001
10 hr	92.86 ± 6.55	85.44 ± 6.01	< 0.001
12 hr	85.26 ± 6.75	78.46 ± 6.18	< 0.001
16 hr	88.58 ± 6.66	81.5 ± 6.03	< 0.001
18 hr	89.34 ± 6.86	82.26 ± 6.27	< 0.001
24 hr	80.82 ± 5.65	74.38 ± 5.19	< 0.001
36 hr	76.8 ± 7.24	74.24 ± 8.67	0.1121
48 hr	75.4 ± 8.02	74.64 ± 7.34	0.6222

Table 4. O2 saturation. Changes postoperatively between the two studied groups.

	Group I (N = 50)	Group II (N = 50)	P. Value
30 min.	95.18 ± 1.91	95.76 ± 4.13	0.3696
1 hr	96.82 ± 1.93	97.08 ± 4.65	0.7159
2 hr	94.28 ± 2.41	96.28 ± 2.41	0.0001
4 hr	95.3 ± 2.94	97.3 ± 2.94	0.001
6 hr	93.1 ± 0.93	95.1 ± 0.93	< 0.001
8 hr	93.4 ± 2.25	95.4 ± 2.25	< 0.001
10 hr	91 ± 0.99	93 ± 0.99	< 0.001
12 hr	96.28 ± 1.11	98.28 ± 1.11	< 0.001
16 hr	95.52 ± 1.76	97.52 ± 1.76	< 0.001
18 hr	94.46 ± 2.11	96.46 ± 2.11	< 0.001
24 hr	96.62 ± 4.8	97.08 ± 2.64	0.5539
36 hr	96.98 ± 5.05	97.6 ± 2.55	0.4403
48 hr	99.02 ± 3.58	99.16 ± 1.56	0.8

Table 5. Respiratory rate. Changes postoperatively between the two studied groups.

	Group I (N = 50)	Group II (N = 50)	P. Value
30 min.	24.22 ± 2.53	23.78 ± 4.79	0.5675
1 hr	20.24 ± 2.02	19.24 ± 2.02	0.0148
2 hr	17.42 ± 1.68	16.42 ± 1.68	0.0037
4 hr	16.14 ± 1.5	15.14 ± 1.5	0.0012
6 hr	17.36 ± 1.38	16.36 ± 1.38	0.0005
8 hr	18.28 ± 1.71	17.28 ± 1.71	0.0044
10 hr	16.88 ± 1.91	15.88 ± 1.91	0.0104
12 hr	15.44 ± 1.36	14.44 ± 1.36	0.0004
16 hr	14.24 ± 1.33	13.24 ± 1.33	0.0003
18 hr	14.48 ± 1.33	13.48 ± 1.33	0.0003
24 hr	15.36 ± 1.48	14.36 ± 1.48	0.0011
36 hr	14.94 ± 4.75	14.18 ± 1.35	0.279
48 hr	14.54 ± 4.97	13.92 ± 1.26	0.3942

Table 6. Postoperative VAS Score in the two studied groups.

	Group I (N = 50)	Group II (N = 50)	P. Value
30 min.	2.4 ± 0.49	2.24 ± 0.43	0.088
1 hr	2.92 ± 0.57	2.02 ± 0.55	< 0.001
2 hr	3.54 ± 0.5	1.5 ± 0.51	< 0.001
4 hr	3.06 ± 0.65	1.94 ± 0.59	< 0.001
6 hr	3.02 ± 0.65	1.98 ± 0.51	< 0.001
8 hr	3.92 ± 0.67	1.88 ± 0.59	< 0.001
10 hr	4 ± 0.57	2.12 ± 0.66	< 0.001
12 hr	5.86 ± 0.7	2.68 ± 0.65	< 0.001
16 hr	5 ± 0.53	2.04 ± 0.53	< 0.001
18 hr	2.88 ± 0.56	1.72 ± 0.61	< 0.001
24 hr	2.7 ± 0.46	1.58 ± 0.5	< 0.001
36 hr	2.34 ± 0.48	1.44 ± 0.5	< 0.001
48 hr	1.56 ± 0.5	1.4 ± 0.49	0.1115

Table 7. Ramsay Sedation Scale in the two studied groups.

	Group I(N = 50)	Group II(N = 50)	P. Value
30 min.	1.5 ± 0.52	1.38 ± 0.5	0.492
1 hr	1.44 ± 0.51	1.56 ± 0.51	0.4955
2 hr	2.56 ± 0.51	2.44 ± 0.51	0.4955
4 hr	2.25 ± 0.45	3 ± 0.82	0.0031
6 hr	2.5 ± 0.52	3.13 ± 0.72	0.0083
8 hr	2.81 ± 0.83	4 ± 0.82	0.0003
10 hr	3.06 ± 0.77	4.38 ± 0.72	< 0.001
12 hr	3.81 ± 0.75	5.19 ± 0.83	< 0.001
16 hr	4.19 ± 0.91	5.63 ± 0.5	< 0.001
18 hr	2.88 ± 0.89	5 ± 0.73	< 0.001
24 hr	3 ± 0.82	3.94 ± 0.85	0.0035
36 hr	3.06 ± 0.93	4.56 ± 0.51	< 0.001
48 hr	1.63 ± 0.72	3.13 ± 0.81	< 0.001

Table 8. Postoperative Morphine consumption among the studied groups.

	Group I (N = 50)	Group II (N = 50)	P. Value
30 min.	3.57 ± 0.61	3.58 ± 0.33	0.9347
1 hr	4.71 ± 0.56	4.81 ± 0.45	0.58
2 hr	6.61 ± 0.4	5.26 ± 0.49	< 0.001
4 hr	6.89 ± 0.42	5.48 ± 0.51	< 0.001
6 hr	7.45 ± 0.45	5.93 ± 0.55	< 0.001
8 hr	8.44 ± 0.51	6.71 ± 0.63	< 0.001
10 hr	8.86 ± 0.54	7.05 ± 0.66	< 0.001
12 hr	9 ± 0.55	7.16 ± 0.67	< 0.001
16 hr	9.7 ± 0.59	7.72 ± 0.72	< 0.001
18 hr	10.83 ± 0.66	8.61 ± 0.81	< 0.001
24 hr	10.97 ± 0.67	8.73 ± 0.82	< 0.001
36 hr	13.08 ± 0.79	10.4 ± 0.97	< 0.001
48 hr	14.06 ± 0.85	11.19 ± 1.05	< 0.001

Table 9. Postoperative nausea and vomiting among the studied groups.

	Group I (N = 50)		Group II (N = 50)		P. Value
	N	%	N	%
30 min.	0	0%	0	0%	-
1 hr	0	0%	0	0%	-
2 hr	0	0%	0	0%	-
4 hr	0	0%	0	0%	-
6 hr	0	0%	0	0%	-
8 hr	12	24%	4	8%	0.029
10 hr	10	20%	3	6%	0.037
12 hr	7	14%	1	2%	0.027
16 hr	0	0%	0	0%	-
18 hr	0	0%	0	0%	-
24 hr	8	16%	2	4%	0.046
36 hr	5	10%	3	6%	0.46
48 hr	3	6%	1	2%	0.31

Table 10. Post-operative pruritus among the studied groups.

	Group I (N = 50)		Group II (N = 50)		P. Value
	N	%	N	%
30 min.	4	8%	2	4%	0.3997
1 hr	0	0%	0	0%	-
2 hr	0	0%	0	0%	-
4 hr	0	0%	0	0%	-
6 hr	0	0%	0	0%
8 hr	15	23%	5	8%	0.012
10 hr	13	26%	4	8%	0.017
12 hr	9	14%	1	2%	0.008
16 hr	0	0%	0	0%	-
18 hr	0	0%	0	0%	-
24 hr	0	0%	0	0%	-
36 hr	0	0%	0	0%	-
48 hr	4	8%	1	2%	0.169