The pregabalin effect on opioid consumption and postoperative pain in spinal fusion surgery, a prospective, randomized, controlled study

Figures & data

Figure 1. Participant flow diagram.

Table 1. Baseline data of studied groups.

	Pregabalin group (n = 45)	Placebo group (n = 45)	P value
Age (years)	41.39 ± 11.23	44.74 ± 10.94	0.15
Sex Male Female	33 (73.3%) 12 (26.7%)	27 (60%) 18 (40%)	0.13
BMI (kg/m^2)	26.67 ± 2.93	25.65 ± 3.93	0.16
Diabetes mellitus	6 (13.3%)	4 (8.9%)	0.37
Hypertension	4 (8.9%)	8 (17.8%)	0.17
Smoking	7 (15.6%)	8 (17.8%)	0.50
ASA class Class-I Class-II	34 (75.6%) 11 (24.4%)	36 (80%) 9 (20%)	0.40

Data expressed as mean (SD), range, frequency (percentage). P value was significant if < 0.05. ASA: American Society of Anesthesiologists; BMI: body mass index

Table 2. Types of spinal surgeries of studied groups.

	Pregabalin group (n = 45)	Placebo group (n = 45)	P value
Types of spinal surgeries Single-level spinal fusion Double-level spinal fusion	36 (80%) 9 (20%)	41 (91.1%) 4 (8.9%)	0.134

Data expressed as frequency (percentage). P value was significant if < 0.05

Table 3. VAS, time to first patients’ request of analgesia (min) and total 24 hours’ morphine consumption in both groups.

	Pregabalin group (n = 45)	Placebo group (n = 45)	P value
Total 24 hr morphine consumption (mg)	8.67 ± 2.20	14.45 ± 2.50	<0.001*
Time to first request of analgesia (min)	210.1 ± 7.3	167.16 ± 12.2	<0.001*
Postoperative VAS At 1 hour	2.75 ± 1.04	3.88 ± 1.77	< 0.001*
At 2 hours	2.22 ± 1.04	3.06 ± 1.43	0.002*
At 4 hours	2.33 ± 1.15	3.00 ± 1.20	0.009*
At 24 hours	2.49 ± 1.08	2.98 ± 1.21	0.04*

Data was expressed in form of mean (SD). P value was significant if < 0.05. VAS: visual analogue score.

Figure 2. Change in the heart rate during the current study.

Figure 3. Change in mean blood pressure during the current study.