Hematological, Biochemical and Hemodynamic Changes during Operative Hysteroscopy using Consecutive Distension Media

Figures & data

Figure 1. Flow Chart

Table 1. Demographic and operative data.

	Study group (n = 30)	Control group (n = 30)	P value
Age (years)	27.83 ± 4.82	28.70 ± 4.28	0.46
Body mass index (kg/m^2)	24.84 ± 3.01	27.33 ± 3.42	0.40
Type of operation			0.93
Polypectomy	20 (66.7%)	19 (63.3%)
Simple polypectomy	10 (33.3%)	8 (42.1%)
Submcous myoma
Type 0	6 (20%)	8 (26.66%)
Type 1	4 (13.3%)	3(10%)
Adhesiolysis	6 (20%)	6 (20%)
Metroplasty	4 (13.3%)	5 (16.7%)
Proper visualization of the lesion	22(73.3%)	12(40%)	0.019*
Completed procedure	100%	100%
Intraoperative complications (specify if present)	0% (none)	0% (none)
Surgeon’s satisfaction score:			0.03*
-Disappointed.	4 (13.3%)	14 (46.7%)
- Mildly satisfied.	4 (13.3%)	4 (13.3%)
- Satisfied.	13 (43.3%)	6 (20%)
- Very satisfied	9 (30%)	6 (20%)
Duration of anesthesia (minutes)	33.16 ± 8.93	33.73 ± 10.86	0.82
Duration of surgery (minutes)	26.03 ± 6.38	27.33 ± 10.31	0.55

Data expressed as frequency (percentage), mean (SD).P value was significant if < 0.05. All data were compared with Student t-test except for the type of operation that was compared by the Chi² test.

Table 2. Hemodynamic parameters.

	Pre-induction	At induction	15 minutes after induction	30 minutes after induction	45 minutes after induction	At recovery	After 6 hours	After 24 hours
MBP (mmHg)
Study group (n = 30)	55.73 ± 5.98	56.80 ± 7.04	57.56 ± 5.11	57.29 ± 6.93	62 ± 9.22	61.90 ± 9.11*	61.90 ± 6.99	55.90 ± 6.57
Control group (n = 30)	54.43 ± 5.28	54.90 ± 7.06	55.67 ± 6.54	57.84 ± 7.07*	61.11 ± 5.79*	69.17 ± 7.77*	68.47 ± 7.47*	54.83 ± 6.57
P value	0.45	0.37	0.30	0.34	0.80	< 0.001	0.01	0.53
CVP assessment (cm H2O)
Study group (n = 30)	7.46 ± 1.22	7.57 ± 1.27	7.73 ± 1.20	7.63 ± 1.11	7.80 ± 1.03	8.12 ± 2.11*	7.70 ± 1.14	7.70 ± 1.17
Control group (n = 30)	8.13 ± 1.41	7.63 ± 1.35	8.67 ± 1.98*	9.31 ± 2.62*	9.88 ± 1.45*	9.62 ± 2.10*	9.06 ± 1.81*	8.10 ± 1.49*
P value	0.61	0.10	0.03	< 0.001	< 0.001	< 0.001	0.01	0.25
COP (ml)
Study group (n = 30)	4.99 ± 0.37	5.09 ± 0.34	5.04 ± 0.33	5.02 ± 0.35	5.02 ± 0.39	5.07 ± 0.34*	5.10 ± 0.39
Control group (n = 30)	5.06 ± 0.35	5.07 ± 0.34	5.07 ± 0.34	5.06 ± 0.28	5.16 ± 0.36	4.18 ± 0.33	4.98 ± 0.37
P value	0.42	0.82	0.70	0.65	0.44	< 0.001	0.37
Cardiac index (l/min/m2)
Study group (n = 30)	2.98 ± 0.39	2.99 ± 0.34	2.99 ± 0.45	2.92 ± 0.42	2.97 ± 0.49	2.92 ± 0.42*	2.99 ± 0.44
Control group (n = 30)	2.93 ± 0.43	2.92 ± 0.43	2.87 ± 0.32	3.02 ± 0.42	2.84 ± 0.28	3.40 ± 0.45	2.93 ± 0.35
P value	0.65	0.46	0.25	0.43	0.48	0.03	0.51
SV (ml/beat)
Study group (n = 30)	77 ± 3.01	76.60 ± 2.68	76.90 ± 3.13	76.62 ± 3.04	77 ± 2.40	70.60 ± 2.68	77.30 ± 2.93
Control group (n = 30)	76.43 ± 2.51	76.76 ± 2.73	76.60 ± 2.68	76.31 ± 2.87	75.87 ± 3.56	76.67 ± 2.86	76.93 ± 2.99
P value	0.43	0.81	0.69	0.71	0.43	0.04	0.63
SI (m/m2/beat)
Study group (n = 30)	45.87 ± 5.01	45.63 ± 4.73	46.40 ± 5.88	47.44 ± 5.16	47.50 ± 5.56	47.46 ± 5.14	45.30 ± 4.87
Control group (n = 30)	45 ± 5.04	46 ± 5.16	46.50 ± 4.71	45.90 ± 5.97	47.11 ± 3.65	44.43 ± 5.09	45.80 ± 5.01
P value	0.50	0.77	0.94	0.34	0.86	< 0.001	0.69

Data expressed as frequency (percentage), mean (SD).P value was significant if < 0.05. All data were compared with Student t-test except for the type of operation that was compared by the Chi² test.

Table 3. Fluid absorption, Osmolality, Biochemical and Hematological parameters.

Fluid chart	Normal saline (ml)	Glycine (ml)	Fluid in container (ml)	Absorbed fluid (ml)	Uterine pressure (mmHg)
Study group (n = 30)	1134 ± 252.14	779.33 ± 248.89	876 ± 360.17	637.33 ± 157.43	81.10 ± 6.17
Control group (n = 30)		1115.56 ± 309.94	520 ± 198.44	605 ± 287.18	82.03 ± 9.31
P value		< 0.001	0.45	0.59	0.64
Osmolality (mOsm/kg)	Pre-induction	After 6 hours	After 24 hours
Study group (n = 30)	288.53 ± 2.33	286.87 ± 4.98	288.77 ± 2.32
Control group (n = 30)	287.03 ± 3.56	255.93 ± 7.78	287.46 ± 3.85
P value	0.05	0.01	0.12
HCO3 (mmol/l)	Pre-induction	At induction	15 minute after induction	30 minute after induction	45 minute after induction	At recovery	After 6 hours	After 24 hours
Study group (n = 30)	21.26 ± 2.46	21.11 ± 2.02	21.47 ± 27.56	21.95 ± 2.37	21.92 ± 2.40	21.89 ± 2.33	21.93 ± 2.21	21.67 ± 2.57
control group (n = 30)	22 ± 2.07	21.99 ± 2.11	22.50 ± 2.01	22.64 ± 1.93	22.89 ± 1.61	21.90 ± 2.01	21.60 ± 2.64	22.43 ± 2.40
P value	0.61	0.50	0.10	0.70	0.03	0.90	0.42	0.53
Sodium (mmol/l)	Pre-induction	At induction	15 minute after induction	30 minute after induction	45 minute after induction	At recovery	After 6 hours	After 24 hours
Study group (n = 30)	137.97 ± 3.10	137.87 ± 3.18	138.78 ± 2.99	138.81 ± 3.02	138.30 ± 3.23	139.01 ± 3.12	137.57 ± 3.59	137.70 ± 4.87
control group (n = 30)	136.50 ± 3.08	136.67 ± 4.11	133.63 ± 2.35*	129.88 ± 2.01*	123.75 ± 3.88*	136.56 ± 2.98	136.90 ± 2.66	136.45 ± 4.32*
P value	0.07	0.08	< 0.001	< 0.001	< 0.001	0.31	0.41	0.13
Hemoglobin (gm/dl)	Pre-induction	After 6 hours	After 24 hours
Study group (n = 30)	12.34 ± 0.55	12.46 ± 0.34	11.99 ± 0.97
control group (n = 30)	12.27 ± 0.87	10.11 ± 1.01*	11.53 ± 1.32*
P value	0.63	0.01	0.13
Hematocrit(%)	Pre-induction	After 6 hours	After 24 hours
Study group (n = 30)	32.80 ± 1.47	32.70 ± 2.10	32.63 ± 1.54
control group (n = 30)	32.93 ± 1.47	28.45 ± 2.87*	32 ± 2.25
P value	0.13	0.01	0.12
Platelets count (103/ul)	Pre-induction	After 6 hours	After 24 hours
Study group (n = 30)	186.30 ± 12.24	193.78 ± 5.93*	180.87 ± 11.87*
control group (n = 30)	185.07 ± 13.05	167.89 ± 11.76*	185.87 ± 12.89
P value	0.21	0.03	0.09

Data expressed as frequency (percentage), mean (SD).P value was significant if < 0.05. All data were compared with Student t-test except for the type of operation that was compared by the Chi² test