Propofol/dexmedetomidine Versus Desflaurane Effects on Post Hepatectomy Hepatocellular Injury

Figures & data

Table 1. Demographic data.

Demographic data		Group A (n=15)	Group B (n=15)	P-value
Age (years)		46.20 ± 13.2	49.93 ± 13.6	0.45
BMI (Kg/m2)		28.59 ± 4.7	27.47 ± 3.3	0.45
ASA	I II	6 (40%) 9 (60%)	7 (46.7%) 8 (53.3%)	0.72
Sex	Male Female	7 (46.7%) 8 (53.3%)	8 (53.3%) 7 (46.7%)	0.72

Note: Data are presented as mean ± SD, % = percentage, X²= chi-squared test, A = TIVA group, B = desflurane group, BMI = body mass index, ASA = American Society of Anesthesiologists.

Table 2. Comparison of groups in terms of surgery duration and ischemia time.

Surgery data	Group A (n=15)	Group B (n=15)	P-value
Duration of surgery (min)	308.67 ± 19.9	314.33 ± 20.9	0.45
Ischemic time (min)	13.60 ± 1.2	13.27 ± 1.3	0.48

Note: Data are presented as mean ± SD, A = TIVA group, B = desflurane group.

Table 3. Comparison of AST and ALT levels between groups.

Postoperative lab data	Group A (n=15)	Group B (n=15)	P-value
ALT BL (U/L)	25.07 ± 47.3	37.80 ± 67.9	0.56
ALT 1 (U/L)	224.27 ± 29.7	318.20 ± 52.5	<0.001*
ALT 3 (U/L)	144.47 ± 24.1	226.73 ± 54.4	<0.001*
ALT 6 (U/L)	33.73 ± 11.0	58.40 ± 13.8	<0.001*
AST BL (U/L)	22.80 ± 13.3	47.27 ± 72.6	0.21
AST 1 (U/L)	265.60 ± 22.3	349.27 ± 56.1	<0.001*
AST 3 (U/L)	170.87 ± 23.2	238.00 ± 38.2	<0.001*
AST 6 (U/L)	40.00 ± 13.0	55.33 ± 18.8	0.01*

Note: Data are presented as mean ± SD, A = TIVA group, B = desflurane group, ALT = alanine aminotransferase, AST= aspartate aminotransferase, BL= baseline, * = significant difference.

Table 4. Comparison between groups as regards serum albumin, total and direct bilirubin, PT, and INR.

Postoperative lab data	A group (n=15)	B group (n=15)	P-value
Albumin BL (g/dL)	4.02 ± 0.3	4.20 ± 0.5	0.21
Albumin 1 (g/dL)	3.73 ± 0.2	3.58 ± 0.3	0.15
Albumin 3 (g/dL)	3.58 ± 0.2	3.36 ± 0.2	0.005*
Albumin 6 (g/dL)	3.69 ± 0.1	3.43 ± 0.2	<0.001*
Total billirubin BL (mg/dL)	0.75 ± 0.24	0.60 ± 0.27	0.25
Total billirubin 1 (mg/dL)	1.19 ± 0.4	1.89 ± 0.5	<0.001*
Total billirubin 3 (mg/dL)	1.24 ± 0.2	1.82 ± 0.2	<0.001*
Total billirubin 6 (mg/dL)	0.87 ± 0.1	1.06 ± 0.2	0.01*
Direct billirubin BL (mg/dL)	0.44 ± 0.2	0.33 ± 0.2	0.06
Direct billirubin 1 (mg/dL)	0.87 ± 0.3	1.50 ± 0.6	0.001*
Direct billirubin 3 (mg/dL)	0.73 ± 0.3	1.17 ± 0.2	<0.001*
Direct billirubin 6 (mg/dL)	0.56 ± 0.1	0.62 ± 0.2	0.30
PT BL (sec)	12.35 ± 1.7	12.20 ± 1.5	0.80
PT 1 (sec)	12.70 ± 1.5	16.80 ± 3.4	<0.001*
PT 3 (sec)	12.77 ± 1.1	15.03 ± 2.5	0.003*
PT 6 (sec)	11.80 ± 1.1	11.53 ± 1.5	0.57
INR BL	1.04 ± 0.2	1.08 ± 0.1	0.54
INR 1	1.09 ± 0.1	1.40 ± 0.2	<0.001*
INR 3	1.09 ± 0.1	1.31 ± 0.2	<0.001*
INR 6	1.00 ± 0.1	1.04 ± 0.1	0.31

Note: Data are presented as mean ± SD, A = TIVA group, B= desflurane group, PT = Prothrombin time, sec = second, INR = international normalized ratio, BL = baseline, * = significant difference.

Figure 1. Line graph between groups as regards MAP. Data are presented as mean ± SD, A = TIVA group, B = desflurane group, MAP = mean arterial pressure.

Figure 2. Line graph between groups as regards HR. Data expressed as mean ± SD, A = TIVA group, B = desflurane group, HR = heart rate.