The anti-inflammatory effects of atorvastatin upon the outcome of traumatic brain injury patients: A randomized-controlled double-blind clinical trial

Figures & data

Figure 1. Consort 2010 Flow Diagram

Table 1. Demographic and clinical data of the studied groups.

Variables	Group C n = 10	Group S n = 10	P-value
Gender male/female	10/0	7/3	.62
Weight Kg	86 ± 12.9	77.4 ± 14	.15
Height cm	169.6 ± 6.7	168 ± 6	.65
BMI	26 ± 3.7	23.5	.17
GIT complications	4 (40%)	2(20%)	.62
ICU stay (days)	16.3 ± 7.5	10 ± 5.2	.04
CT brain findings Contusion Edema Subarachnoid hemorrhage Intraventricular hemorrhage	8 (80%) 6 (60%) 6 (60%) 1 (10%)	8 (80%) 8 (80%) 3 (30%) 1 (10%)	.79

Data are expressed as ratio, mean± standard deviation, and or number (percentage). P < 0.05 is considered statistically significant.

Table 2. Magnetic resonance spectroscopy (MRS) findings in the study groups.

Variables	Group C n = 10	Group S n = 10	P-value
Metabolites
Increased NAA	1 (10%)	-	1
Decreased Cho Increased Cho	3 (30%) 1(10%)	6 (60%) -	.3
Decreased Cr Increased Cr	7 (70%) -	6 (60%) 1 (10%)	.58
Cho/Cr	1.75 ± .57	1.02 ± .37	.005
NAA/Cr	1.62 ± .09	1.65 ± .08	.836
NAA/Cho	.83 ± .29	1.33 ± .52	.022

Data are expressed as number (percentage) or mean ± standard deviation. N-Acetyl aspartate (NAA), Choline (Cho) creatine (Cr). P < 0.05 is considered statistically significant.

Table 3. Conscious level of the studied groups.

Variables	Group C n = 10	Group S n = 10	P-value
GCS 0	12.5 [1]	12.5 [1]	-
GCS 1	1.5 [4]	13 [2]	.01
GCS 2	1.5 [5]	14 [1]	.11
RASS 0	1 (0)	−1 (0)	.14
RASS 1	1 (0)	−1 (0)	.02
RASS 2	1 [2]	−1 [1]	.039

Data are expressed median (interquartile range). GCS Glasgow coma scale, RAAS Richmond agitation sedation scale. (0) on admission [1], 1st day of ICU stay [2], 2nd day of ICU stay. P < 0.05 is considered statistically significant.

Table 4. Inflammatory

Variables	Group C n = 10	Group S n = 10	P-value
CRP 0 mg/L	23.80 ± 8.23	34 ± 1.7	.2
CRP 2 mg/l	27.40 ± 8.47	23.78 ± 14.6	.51
Albumin 0 g/L	31.50 ± .980	3.30 ± 1.476	.59
Albumin 2 g/L	29.50 ± .792	3.00 ± 1.5	.81
CAB 0	.7740 ± .09908	1.4750 ± .25	.007
CAB 2	1.035 ± .22*	1.1 ± .30*	.85

Data are presented as mean ± standard deviation. C-reactive protein (CRP), C-reactive protein/albumin ratio (CAB). (0) on admission [2] 2^nd day in the ICU. *Significant change from the base line.

Table 5. Hemodynamics

Variables	Group C n = 10	Group S n = 10	P-value
MBP 0 mm Hg	69 ± 8.367	69.8 ± 8.4	.83
MBP 1 mm Hg	73.60 ± 9.240	69.4 ± 7.98	.29
MBP 2 mm Hg	73.50 ± 1.124	69.5 ± 5.5	.28
HR 0 beat/m	81.20 ± 17.498	73.7 ± 5.9	.21
HR 1 beat/m	78 ± 11.416	73.7 ± 5.5	.28
HR 2 beat/m	79.80 ± 11.989	75.2 ± 7.2	.31

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