Antimicrobial treatment of Kocuria kristinae invasive infections: Systematic review

Abstract

Objective of this systematic review was to establish whether and what invasive infections in humans were caused by Kocuria kristinae, and to evaluate outcomes of administered antibiotic treatment. MEDLINE, EBSCO, SCOPUS, SCINDEKS and GOOGLE SCHOLAR were systematically searched for primary case reports or case series describing invasive infections with K. kristinae. K. kristinae is a pathogen microorganism that could cause invasive infections of various tissues in patients of any age. Majority of the patients had K. kristinae isolated from blood. It was also found in peritoneal fluid, pus, sputum, synovial fluid, bile, fluid from abdominal abscess, throat swab, urine catheter tip and mid-stream urine. Antibiotic treatment was almost universally effective, with only one death reported. Susceptibility was highest to vancomycin, linezolid, rifampicin, teicoplanin, tigecycline, cefotaxime, ampicillin/sulbactam, minocycline and meropenem. Initial treatment of Kocuria kristinae infections should involve parenteral vancomycin in combination with some other antibiotic to which it is susceptible.

Keywords:

• Antibiotic treatment
• Invasive infections
• Kocuria kristinae
• Systematic review

Disclosure statement

The authors report no conflicts of interest.

Additional information

Funding

This work was partially supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia under Grant number 175007. Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja.

Notes on contributors

Radica S. Živković Zarić

Radica S. Živković Zarić (MD) is PhD student of clinical and experimental pharmacology and Research Trainees at Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.

Ana V. Pejčić

Ana V. Pejčić (MPharm) PhD student of clinical and experimental pharmacology and Research Trainees at Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.

Slobodan M. Janković

Slobodan M. Janković (MD, PhD) is a general surgery and clinical pharmacology specialist serving as a Full Professor of pharmacology, toxicology and clinical pharmacy at Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.

Marina J. Kostić

Marina J. Kostić (MD, PhD) is a clinical pharmacology specialist and an Associate Professor of pharmacology and toxicology at Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.

Miloš N. Milosavljević

Miloš N. Milosavljević (MPharm) PhD student of clinical and experimental pharmacology and Research Trainees at Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.

Marko J. Milosavljević

Marko J. Milosavljević (DMD, PhD) is a Research Associate at Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.

Valentina D. Opančina

Valentina D. Opančina (MD) PhD student of clinical and experimental pharmacology and Research Trainees at Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.