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Biotechnology & Biotechnological Equipment Volume 29, 2015 - Issue 1
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Article; Medical Biotechnology

Whole genome microarray analysis in non-small cell lung cancer

Mohammad AL ZeyadiDepartment of Medical Genetics, Faculty of Medicine, Medical University of Sofia, Sofia, BulgariaView further author information
,
Ivanka DimovaDepartment of Medical Genetics, Faculty of Medicine, Medical University of Sofia, Sofia, BulgariaView further author information
,
Vladislav RanchichDepartment of Medical Genetics, Faculty of Medicine, Medical University of Sofia, Sofia, BulgariaView further author information
,
Blaga RukovaDepartment of Medical Genetics, Faculty of Medicine, Medical University of Sofia, Sofia, BulgariaView further author information
,
Desislava NeshevaDepartment of Medical Genetics, Faculty of Medicine, Medical University of Sofia, Sofia, BulgariaView further author information
,
Zora HamudeDepartment of Medical Genetics, Faculty of Medicine, Medical University of Sofia, Sofia, BulgariaView further author information
,
Sevdalin GeorgievDepartment of Medical Genetics, Faculty of Medicine, Medical University of Sofia, Sofia, BulgariaView further author information
,
Danail PetrovClinic of Thoracic Surgery, Medical University of Sofia, Sofia, BulgariaView further author information
&
Draga TonchevaDepartment of Medical Genetics, Faculty of Medicine, Medical University of Sofia, Sofia, BulgariaCorrespondence[email protected]
View further author information
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Pages 111-118 | Received 24 Oct 2014, Accepted 10 Nov 2014, Published online: 19 Jan 2015

Figures & data

Table 1. Clinical data about the analysed lung cancer cases.

Figure 1. Large aberrations such as gains of whole chromosomes (trisomies): trisomy 1 (A), trisomy 13 (B), trisomy 18 (C) and trisomy 20 (D).

Figure 1. Large aberrations such as gains of whole chromosomes (trisomies): trisomy 1 (A), trisomy 13 (B), trisomy 18 (C) and trisomy 20 (D).

Figure 2. Genetic aberrations involving chromosome arms. (A) Gain of the short arm of chromosome 5 (5p+). (B) Gain of the long arm of chromosome 11 (11q+). (C) Gain of the long arm of chromosome 20 (20q+). (D) Gain of the long arm of X chromosome (Xq+).

Figure 2. Genetic aberrations involving chromosome arms. (A) Gain of the short arm of chromosome 5 (5p+). (B) Gain of the long arm of chromosome 11 (11q+). (C) Gain of the long arm of chromosome 20 (20q+). (D) Gain of the long arm of X chromosome (Xq+).

Figure 3. Genetic losses of chromosome arms. (A) Deletion of the long arm of chromosome 10 (10q−). (B) Deletion of the long arm of chromosome 15 (15q−).

Figure 3. Genetic losses of chromosome arms. (A) Deletion of the long arm of chromosome 10 (10q−). (B) Deletion of the long arm of chromosome 15 (15q−).

Table 2. Regional genetic gains.

Table 3. Regional genetic losses.

Table 4. Genetic gains with size <5 Mbp and high amplitude (log2 ratio T/N > 0.5) .

Table 5. Genetic losses with a size of <5 Mbp and high amplitude (log2 ratio T/N < −0.5) .

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