Beneficial effects of crude extract of Eupatorium lindleyanum DC. in hyperlipidemia and atherosclerosis

Figures & data

Figure 1. Effect of CEEL on the serum level of TC (A), TG (B), LDL-C (C) and HDL-C (D). Data are mean values (± SD) from 10 rabbits per group. *p < 0.05, #p < 0.01 versus the model group.

Figure 2. Effect of CEEL on expression of CRP. The data are presented as means ± SD from 10 rabbits per group. *p < 0.05 versus the model group.

Figure 3. Effect of CEEL on concentration of NO in blood. The data are presented as means ± SD from 10 rabbits per group. *p < 0.05 versus the model group.

Table 1. Effect of CEEL on the plaque area and IMT of the aortic in hyperlipidemic rabbits on high cholesterol diets.

Parameter	Control	Model	SVS	H-CEEL	M-CEEL	L-CEEL
Plaque area (% of aorta area)	0	89.61 ± 7.85	14.72 ± 4.07^#	16.97 ± 5.49^#	34.51 ± 9.58*	42.32 ± 6.85*
IMT (mm)	0	245.8 ± 34.6	169.73 ± 24.1#	139.54 ± 17.8#	177.59 ± 24.3*	216.94 ± 34.6

Note: Data are presented as means ± SD from 10 rabbits per group. *p < 0.05, ^#p < 0.01 versus the model group.

Figure 4. Effect of CEEL on the aorta histopathological changes in rabbits fed a high cholesterol diet. Representative photomicrographs of H&E staining.

Figure 5. SDS-PAGE analysis of the VCAM-1 mRNA expression profiles in different groups of animals. M: RNA marker (units in bp), Lane 1: L-CEEL, Lane 2: M-CEEL, Lane 3: H-CEEL, Lane 4: SVS, Lane 5: model, Lane 6: control. GAPDH: internal control.