Impact of IL-10 and IL-12B single nucleotide polymorphisms on circulating cytokine level in development of Hashimoto's thyroiditis

Figures & data

Figure 1. Distribution of allele and genotype frequencies of 3’UTR A/C in IL12B among Hashimoto's thyroiditis (HT) patients and healthy subjects (C).

Table 1. Serum concentrations of IL-12p40 and IL-10 in Hashimoto's thyroiditis (HT) patients and healthy controls.

Cytokine	Controls (n = 72)	HT (n = 124)	Group I* (n = 41)	Group II** (n = 17)	Group III*** (n = 66)
IL-12p40 (pg/mL) mean ± SEМ (range)	62.26 ± 3.62 (6.7–184.2)	77.13 ± 4.69 (3.3–324.7)	82.29 ± 10.1 (10.8–324.7)	83.41 ± 14.1 (25.2–230.2)	72.3 ± 5.11 (3.3–183.4)
IL-10 (pg/mL) mean ± SEМ (range)	0.74 ± 0.22 (0.0–4.4)	1.1 ± 0.54 (0.0–50.0)	0.48 ± 0.3 (0.0–10.45)	1.98 ± 1.59 (0.0–19.48)	1.31 ± 0.94 (0.0–50.0)
Undetectable values†	18.7%	27.5%	33.5%	15%	28%

*Group I, patients in euthyroid stage.

**Group II, patients with hypothyroidism.

***Group III, patients treated with levothyroxine.

†The percentage of subjects with undetectable serum levels of the cytokine.

Figure 2. Serum levels of IL-12p40 in Hashimoto's thyroiditis (HT) patients and controls (C). EU – patients in euthyroid stage; HYPO – patients with hypothyroidism; TREATMENT – patients treated with levothyroxine. Results are presented as mean values with standard errors of the means (±SEМ).

Figure 3. Serum levels of IL-12p40 in Hashimoto's thyroiditis (HT) patients and controls (C) according to the genotypes of the 3’UTR A/C IL12B polymorphism. Results are presented as means ±SEМ.

Figure 4. Serum levels of IL-10 in Hashimoto's thyroiditis (HT) patients and controls (C). EU – patients in euthyroid stage; HYPO – patients with hypothyroidism; TREATMENT – patients treated with levothyroxine. Results are presented as means ±SEМ.

Figure 5. Serum levels of IL-10 in Hashimoto's thyroiditis (HT) patients (EU – patients in euthyroid stage; HYPO – patients with hypothyroidism) according to the −1082 A/G IL10 SNP genotypes. Results are presented as means values ±SEМ.

Figure 6. Distribution of allele and genotype frequencies of −1082 A/G in IL-10 among Hashimoto's thyroiditis (HT) patients and healthy subjects (C).