Effects of Prunus tomentosa total flavone on adjuvant-induced arthritis

Figures & data

Table 1. Effect of PTTF on the swelling degree of ankle joint in AA rats ($\overline{x}\pm s$)

		Left ankle swelling (mL)
Groups	Dose (mg/kg)	Before modelling	3rd day	6th day	9th day	12th day	15th day	18th day	21st day	24th day
Normal group	–	1.30 ± 0.08	1.39 ± 0.10	1.42 ± 0.21*	1.44 ± 0.14*	1.43 ± 0.15**	1.44 ± 0.12*	1.51 ± 0.12**	1.51 ± 0.14**	1.54 ± 0.19**
CFA model group	–	1.33 ± 0.10	1.50 ± 0.12	1.75 ± 0.07	1.77 ± 0.14	1.78 ± 0.09	1.78 ± 0.14	1.89 ± 0.12	1.90 ± 0.13	1.93 ± 0.10
Dexamethasone group	5	1.24 ± 0.16	1.52 ± 0.09	1.72 ± 0.14	1.64 ± 0.13	1.71 ± 0.15	1.70 ± 0.11	1.52 ± 0.09**	1.42 ± 0.15**	1.59 ± 0.13**
PTTF low-dose group	3.5	1.42 ± 0.20	1.53 ± 0.09	1.65 ± 0.13	1.76 ± 0.27	1.61 ± 0.09	1.72 ± 0.07	1.82 ± 0.07	1.80 ± 0.09	1.80 ± 0.15
PTTF medium-dose group	7	1.40 ± 0.09	1.46 ± 0.12	1.51 ± 0.08	1.69 ± 0.10	1.77 ± 0.13	1.72 ± 0.12	1.78 ± 0.14*	1.74 ± 0.12*	1.68 ± 0.12*
PTTF high-dose group	14	1.24 ± 0.16	1.47 ± 0.13	1.59 ± 0.26	1.63 ± 0.21	1.68 ± 0.29	1.64 ± 0.21	1.69 ± 0.25*	1.65 ± 0.18**	1.62 ± 0.19**

Note: Compared with the CFA model group, *P < 0.05, **P < 0.01.

Table 2. Effect of PTTF on the organ index of AA rats ($\overline{x}\pm s$).

		Organ index (%)
Groups	Dose (mg/kg)	Thymus	Spleen
Normal group	–	2.08 ± 0.35	2.88 ± 0.72
CFA model group	–	1.82 ± 0.24	2.71 ± 0.35
Dexamethasone group	5	1.97 ± 0.72	2.83 ± 0.49
PTTF low-dose group	3.5	1.99 ± 0.38	3.12 ± 0.68*
PTTF medium-dose group	7	2.01 ± 0.39	3.24 ± 0.43*
PTTF high-dose group	14	1.99 ± 0.29	3.43 ± 0.58*

Note: Compared with the CFA model group, *P < 0.05.

Figure 1. Histopathological observation of the ankle joint of adjuvant arthritis in rats ( ×400). Normal group (a); CFA model group (b); dexamethasone group (c); PTTF 3.5-mg/kg-dose group (d); PTTF 7-mg/kg-dose group (e); PTTF 14-mg/kg-dose group (f).

Table 3. Effect of PTTF on NO, NOS and PGE₂ in serum of AA rats ($\overline{x}\pm s$).

Groups	Dose (mg/kg)	NO (ng/g)	NOS (ng/g)	PGE2 (ng/g)
Normal group	–	23.84 ± 5.92**	14.46 ± 3.82**	1.83 ± 0.61**
CFA model group	–	70.41 ± 12.04	52.96 ± 10.26	4.46 ± 0.86
PTTF low-dose group	3.5	66.91 ± 7.28	43.16 ± 2.91	4.31 ± 0.52
PTTF medium-dose group	7	53.17 ± 8.82**	37.08 ± 2.84**	3.35 ± 0.74**
PTTF high-dose group	14	47.25 ± 8.97**	29.13 ± 3.05**	3.06 ± 0.71**

Note: Compared with the CFA model group, *P < 0.05, **P < 0.01.