Calcitonin related polypeptide alpha gene polymorphisms according to plasma total homocysteine levels in ischemic stroke patients of Trakya Region

Figures & data

Table 1. Clinical results in patients and control subjects.

	Groups
Clinical results	Patients (n = 82)	Controls (n = 92)	p
Hypertension, n (−/+)	27/55	56 / 36	<0.001^a*
Diabetes mellitus, n (−/+)	58/24	81 / 11	0.008^a*
Undergone CVD, n (−/+)	56/26	92 / 0	<0.001^a*
Smoking, n (−/+)	62/20	84 / 8	0.009^a*
Alcohol use, n (−/+)	67/15	88 / 4	0.007^a*
Heart diseases, n (−/+)	64/18	91 / 1	<0.001^a*
	Mean ± SD	Mean ± SD
Fasting blood glucose (mg/dL)	122.72 ± 57.38	90.91 ± 18.36	<0.001^b*
Triglyceride (mg/dL)	141.41 ± 82.69	124.94 ± 49.70	0.790^b
HDL (mg/dL)	40.20 ± 10.21	49.10 ± 12.61	<0.001^c*
LDL (mg/dL)	121.58 ± 35.59	128.71 ± 35.31	0.271^c

Note: CVD, cerebrovascular diseases; LDL, low density lipoprotein; HDL, high density lipoprotein.

−/+: Nonexistent/existent

^a Chi-squared test;

^b Mann–Whitney test,

^c Independent samples test;

^* significant differences

Table 2. CALCA T692C gene polymorphism genotype distributions.

CALCA (T692C)	Groups
Genotypes/allele frequencies	Patients	Controls	p
CC	4 (5%)	3 (3%)
CT	36 (44%)	40 (44%)	0.853^a
TT	42 (51%)	49 (53%)
T allele frequency	120 (73%)	138 (75%)	0.697^a
C allele frequency	44 (27%)	46 (25%)

^a Chi-squared test

Table 3. CALCA -1786T>C gene polymorphism genotype distributions.

CALCA (-1786T > C)	Groups
Genotypes/allele frequencies	Patients	Controls	p
CC	4 (5%)	3 (3%)
CT	32 (39%)	40 (44%)	0.758^a
TT	46 (56%)	49 (53%)
T allele frequency	124 (76%)	138 (75%)	0.895^a
C allele frequency	40 (24%)	46 (25%)

^a Chi-squared test

Table 4. CALCA -624 (T/C) gene polymorphism genotype distributions.

CALCA (-624 (T/C))	Groups
Genotypes/allele frequencies	Patients	Controls	p
CC	6 (7%)	5 (5%)
CT	31(38%)	34 (37%)	0.857^a
TT	45 (55%)	53 (58%)
T allele frequency	124 (76%)	140 (76%)	0.917^a
C allele frequency	40 (24%)	44 (24%)

^a Chi-squared test

Table 5. CALCA T692C gene polymorphisms genotype distributions according to plasma total homocysteine levels.

	Plasma total homocysteine levels (µmol/L)
CALCA T692C genotype distributions	Patients Mean ± SD	Controls Mean ± SD	p
CC	17.575 ± 6.6720	17.773 ± 7.4198	0.724^a
CT	22.383 ± 11.8721	18.335 ± 7.1535	0.310^a
TT	18.604 ± 9.2520	18.849 ± 7.7748	0.561^a

^a Mann–Whitney test

Table 6. CALCA -1786T>C gene polymorphisms genotype distributions according to plasma total homocysteine levels.

	Plasma total homocysteine levels (µmol/L)
CALCA -1786T>C genotype distributions	Patients Mean ± SD	Controls Mean ± SD	p
CC	20.350 ± 8.6893	12.060 ± 3.6369	0.157^a
CT	23.478 ± 11.8305	18.760 ± 7.0803	0.163^a
TT	17.930 ± 9.1115	18.849 ± 7.7748	0.258^a

^a Mann–Whitney test

Table 7. CALCA -624 (T/C) gene polymorphisms genotype distributions according to plasma total homocysteine levels.

	Plasma total homocysteine levels (µmol/L)
CALCA -624 (T/C) genotype distributions	Patients Mean ± SD	Controls Mean ± SD	p
CC	18.450 ± 7.3544	12.736 ± 3.2744	0.200^a
CT	23.007 ± 11.9644	19.474 ± 7.0637	0.470^a
TT	18.523 ± 9.4486	18.574 ± 7.7560	0.559^a

^a Mann–Whitney test

Table 8. CALCA T692C gene polymorphisms genotype distributions according to plasma total homocysteine levels (µmol/L) in the subtypes of patients.

CALCA T692C genotype distribution	LVD Mean ± SD	SVD Mean ± SD	Cardio Mean ± SD	Cryptogenic Mean ± SD	OU Mean ± SD
CC	–	22.250 ± 6.5761	–	–	–
CT	22.698 ± 14.5559	28.950 ± 10.5362	21.549 ± 12.4276	19.775 ± 8.7194	–
TT	19.588 ± 8.9539	28.700 ± 14.5842	16.214 ± 7.7889	21.040 ± 9.3168	16.045 ± 7.2676
p	0.663^b	0.752^a	0.534^b	0.770^b	–

Note: LVD, large vessel disease; SVD, small vessel disease; OU: other unclassified; Cardio, cardioembolic stroke

^a Kruskal–Wallis test;

^b Mann–Whitney test

Table 9. CALCA -1786T>C gene polymorphisms genotype distributions according to plasma total homocysteine levels (µmol/L) in the subtypes of patients

CALCA -1786T>C genotype distribution	LVD Mean ± SD	SVD Mean ± SD	Cardio Mean ± SD	Cryptogenic Mean ± SD	OU Mean ± SD
CC	–	27.800 ± 1.2728	–	–	–
CT	24.888 ± 14.0884	27.100 ± 11.5176	23.229 ± 13.0272	20.900 ± 8.7685	–
TT	17.987 ± 9.3949	28.700 ± 14.5842	15.948 ± 7.4854	19.517 ± 9.1305	16.045 ± 7.2676
p	0.420^b	0.911^a	0.258^b	0.668^b	–

Note: LVD, large vessel disease; SVD, small vessel disease; OU: other unclassified; Cardio, cardioembolic stroke

^a Kruskal–Wallis test;

^b Mann–Whitney test

Table 10. CALCA -624 (T/C) gene polymorphisms genotype distributions according to plasma total homocysteine levels (µmol/L) in the subtypes of patients

CALCA -624 (T/C) genotype distribution	LVD Mean ± SD	SVD Mean ± SD	Cardio Mean ± SD	Cryptogenic Mean ± SD	OU Mean ± SD
CC	12.900 ± 1.6971	27.800 ± 1.2728	14.650 ± 0.7778	–	–
CT	24.366 ± 14.6120	27.100 ± 11.5176	24.066 ± 13.5341	18.300 ± 6.4104	–
TT	18.994 ± 9.5100	28.700 ± 14.5842	15.970 ± 7.4808	22.550 ± 10.7649	16.045 ± 7.2676
p	0.564^a	0.911^a	0.241^a	0.668^b	–

Note: LVD, large vessel disease; SVD, small vessel disease; OU: other unclassified; Cardio, cardioembolic stroke

^a Kruskal–Wallis test;

^b Mann–Whitney test