A comparative histopathological and immunohistochemical study of Survivin and Ki-67 proteins in glial tumours

Figures & data

Figure 1. Survivin-stained, low-grade (A) and high-grade (B) glial tumour (x400).

Figure 2. Ki-67-stained, low-grade (A) and high-grade (B) glial tumour (x400).

Figure 3. Relationship between survivin and Ki-67.

Table 1. Evaluations by gender.

	Gender		pa
	Female(n:6)	Male(n:23)
	Mean ± SD (median)	Mean ± SD (median)
Ki-67(%)	27.66 ± 19.66 (30)	27.21 ± 16.51 (30)	0.892
Survivin protein (%)	27.16 ± 22.49 (17.5)	23.82 ± 17.48 (20)	0.850
Age (Mean ± SD)	50.96 ± 13.30
Tumour size	n (%)	n (%)	p-value
<5 cm	4 (66.7)	11 (47.8)	0.651b
≥5 cm	2 (33.3)	12 (52.2)
Survivin Genotype*
GG	4 (80.0)	6 (30.0)	0.198c
GC	1 (20)	11 (55.0)
CC	0	3 (15.0)

^aMann–Whitney U test.

^bFisher exact test.

^cFisher Freeman Halton test.

*The genotype could not be determined in 4 patients (female: 1 and male:3).

Table 2. Relationship of tumour grades with survivin protein and Ki-67 grade.

	Tumour grade
	r	p
Survivin protein	0.345	0.067
Ki-67	0.663	0.001**

r: Spearman correlation coefficients.

**p < 0.01.

Table 3. Distribution of survivin genotypes.

		n (number of patients)	%
Genotype	Unknown	4	13.8
	CC	3	10.3
	GC	12	41.4
	GG	10	34.5
Allele	C-allele	18	36.0
	G-allele	32	64.0