Evaluation of nitric oxide levels in chronic periodontitis patients treated with initial periodontal therapy and probiotic food supplements: a double blind, randomized controlled clinical trial

Figures & data

Table 1. Baseline data of the patients in both groups.

	Test group (IPT + probiotic)	Control group (IPT + placebo)
	n = 18	n = 18
	Mean ± SD	Mean ± SD	p
Age*	45.4 ± 3.39	46.8 ± 4.25	0.65
Gender† (F/M)	7/11	9/9	0.73
BoP (%)*	84.23 ± 0.7	83.75 ± 1.1	0.693
PD (mm)	4.47 ± 0.61	4.38 ± 0.52	0.766
GCF volume* (µL)	0.56 ± 0.32	0.53 ± 0.14	0.64
NO* (µmol dL^−1)	86.41 ± 19.18	85.52 ± 22.75	0.89

^†Chi-square test, *Student’s t test. Values are statistically significant at p < 0.05.

BoP: bleeding on probing; PD: probing depth; GCF: gingival crevicular fluid; NO: nitric oxide.

Table 2. Inter- and intragroup comparisons of the parameters at baseline and 3 and 6 months.

		Baseline	3 months	6 months	p*
		Mean ± SD	Mean ± SD	Mean ± SD
GCF volume (µL)	Test group n = 18	0.56 ± 0.32	0.15 ± 0.09	0.11 ± 0.01	0.001
	Control group n = 18	0.53 ± 0.14	0.27 ± 0.03	0.19 ± 0.08	0.001
	p**	0.63	0.008	0.002
NO µmol/dL	Test group n = 18	86.41 ± 19.18	39.41 ± 11.83	56.12 ± 15.15	0.001
	Control group n = 18	85.52 ± 22.75	53.76 ± 21.02	65.31 ± 19.31	0.001
	p**	0.82	0.001	0.009
PD (mm)	Test group n = 18	4.47 ± 0.61	2.95 ± 0.36	2.92 ± 0.29	0.001
	Control group n = 18	4.38 ± 0.52	3.67 ± 0.25	3.8 ± 0.72	0.001
	p**	0.766	0.001	0.001
BoP (%)	Test group n = 18	84.23 ± 2.7	14.6 ± 3.26	12.67 ± 4.98	0.001
	Control group n = 18	83.75 ± 1.1	23.11 ± 5.64	19.08 ± 3.55	0.001
	P**	0.693	0.001	0.001

* One-way ANOVA test,

** Student’s t test. Values are statistically significant at p < 0.05.

GCF: gingival crevicular fluid; NO: nitric oxide; PD: probing depth; BoP: bleeding on probing.