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Biotechnology & Biotechnological Equipment Volume 34, 2020 - Issue 1
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Article

Paroxetine can improve primary visual cortex activity in a high-risk mouse model of schizophrenia

Xinying Chena Department of Psychiatric-Neuroimging-Genetics and Comorbidity Laboratory (PNGC_Lab), Tianjin Anding Hospital, Tianjin, PR ChinaView further author information
,
Ziyao Caib Department of Psychiatry and Micro-imaging Centre, Wenzhou Seventh People’s Hospital, Wenzhou, PR ChinaView further author information
,
Feng Jic Department of Psychiatry, School of Mental Health, Jining Medical University, Jining, PR ChinaView further author information
,
Xiaodong Linb Department of Psychiatry and Micro-imaging Centre, Wenzhou Seventh People’s Hospital, Wenzhou, PR ChinaView further author information
,
Deguo Jiangb Department of Psychiatry and Micro-imaging Centre, Wenzhou Seventh People’s Hospital, Wenzhou, PR ChinaView further author information
,
Chongguang Linb Department of Psychiatry and Micro-imaging Centre, Wenzhou Seventh People’s Hospital, Wenzhou, PR ChinaView further author information
,
Xiaoyan Maa Department of Psychiatric-Neuroimging-Genetics and Comorbidity Laboratory (PNGC_Lab), Tianjin Anding Hospital, Tianjin, PR ChinaView further author information
,
Yong Xud Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, PR China;e MDT Center for Cognitive Impairment and Sleep Disorders, First Hospital of Shanxi Medical University, Taiyuan, PR ChinaView further author information
,
Wenqiang Wangf Canada and China Joint Laboratory of Biological Psychiatry, Xiamen Xianye Hospital, Xiamen, Fujian, PR China;View further author information
,
Lidan Zhenga Department of Psychiatric-Neuroimging-Genetics and Comorbidity Laboratory (PNGC_Lab), Tianjin Anding Hospital, Tianjin, PR ChinaView further author information
,
Ce Chena Department of Psychiatric-Neuroimging-Genetics and Comorbidity Laboratory (PNGC_Lab), Tianjin Anding Hospital, Tianjin, PR ChinaView further author information
&
Chuanjun Zhuoa Department of Psychiatric-Neuroimging-Genetics and Comorbidity Laboratory (PNGC_Lab), Tianjin Anding Hospital, Tianjin, PR China;b Department of Psychiatry and Micro-imaging Centre, Wenzhou Seventh People’s Hospital, Wenzhou, PR China;c Department of Psychiatry, School of Mental Health, Jining Medical University, Jining, PR China;g Key Laboratory of Real Time Brain Circuits Tracing Of Neurology and Psychiatry (RTBNB_Lab), Tianjin fourth center Hospital, Tianjin Medical affiliated Tianjin Fourth Central Hospital, Nankai University affiliated Tianjin Fourth Center Hospital, Tianjin, PR ChinaCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-3793-550XView further author information
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Pages 1299-1303 | Received 07 Jan 2020, Accepted 09 Oct 2020, Published online: 22 Oct 2020

Figures & data

Figure 1. Neuronal activity in visual cortex and behavioural phenotyping. (A) Representative pseudo-coloured images showing the calcium activity in the visual cortex. (B) Quantification of total integrated calcium activities in the primary visual cortex. (C) Prepulse inhibition (in %) from different treatment groups. (D) Novel object recognition ratios of all animals. Note: ns, non-significant (p > 0.05); *p < 0.05, **p < 0.01, ***p < 0.001.

Figure 1. Neuronal activity in visual cortex and behavioural phenotyping. (A) Representative pseudo-coloured images showing the calcium activity in the visual cortex. (B) Quantification of total integrated calcium activities in the primary visual cortex. (C) Prepulse inhibition (in %) from different treatment groups. (D) Novel object recognition ratios of all animals. Note: ns, non-significant (p > 0.05); *p < 0.05, **p < 0.01, ***p < 0.001.

Data availability statement

The datasets generated and analysed during the present study are available from the corresponding author on reasonable request.

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