Ecballium elaterium extract reduces fibrosis during wound healing in rats

Figures & data

Figure 1. Prominent fibrosis is observed in wound healing in S-14 group (HE, ×40).

Figure 2. Minimal fibrosis is observed in wound healing in EE-14 group (HE; ×40).

Figure 3. Significant fibrosis (left) was observed in the S-14 group, while mild fibrosis (right) was noted in the EE-14 group. (Masson Trichrome; ×40).

Table 1. Histopathological and immunohistochemical data.

Groups	S-7	EE-7	7-p value	S-14	EE-14	14-p value
Severity of inflammation	2	3	0.310	3	6	0.094
Vascularization	0	3	0.135	3	6	0.094
Fibrosis	6	5	0.515	6	2	0.031
The nature of inflammation	0	1	0.299	2	5	0.109
Inflammation of surrounding tissue	1	0	0.299	2	5	0.109
Liver	6	7	0.299	7	7	–
Pancreas	0	0	–	0	0	–
CD34	5	5	1.000	6	4	0.237
Caspase 3	4	2	0.280	6	3	0.094

S-7: Saline group sacrificed on day 7; EE-7: EE group sacrificed on day 7; S-14: Saline group sacrificed on day 14; EE-14: EE group sacrificed on day 14; 7-p: p values for the day 7 data; 14-p: p values for day 14 data.

Data availability

Data supporting the findings from this study can be obtained from the corresponding author upon reasonable request.