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Biotechnology & Biotechnological Equipment Volume 36, 2022 - Issue 1
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Articles

Assaying for antiviral activity of the folkloric medicinal desert plant Rhazya stricta on coronavirus SARS-CoV-2

Mohammed N. Baeshena Department of Biology, College of Science, University of Jeddah, Saudi ArabiaORCID Iconhttps://orcid.org/0000-0002-0235-5222View further author information
ORCID Icon,
Roba Attara Department of Biology, College of Science, University of Jeddah, Saudi ArabiaCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0003-4938-0553View further author information
ORCID Icon,
Thamer A. Boubackb Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Saudi ArabiaView further author information
,
Abdulaziz O. Albeshrib Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Saudi ArabiaView further author information
,
Naseebh N. Baeshenc Department of Biology, College of Sciences and Arts, University of Jeddah, Saudi ArabiaCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0001-7580-0406View further author information
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Alaa Karkashana Department of Biology, College of Science, University of Jeddah, Saudi ArabiaView further author information
,
Basma Abbasa Department of Biology, College of Science, University of Jeddah, Saudi ArabiaView further author information
,
Abdullah A. Aljaddawib Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Saudi ArabiaORCID Iconhttps://orcid.org/0000-0002-2834-1291View further author information
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Yaaser Q. Almulaikyd Department of Chemistry, College of Sciences and Arts, University of Jeddah, Saudi ArabiaView further author information
,
Sara H. Mahmoude Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, EgyptView further author information
,
Noura M. Abo Shamae Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, EgyptView further author information
,
Mohamed A. Alie Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, EgyptView further author information
,
Moayad Baadhaimf King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard – Health Affairs, Saudi ArabiaView further author information
,
Samer Zakrif King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard – Health Affairs, Saudi ArabiaView further author information
,
Khaled Alsayeghf King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard – Health Affairs, Saudi ArabiaView further author information
,
Arif Mohammeda Department of Biology, College of Science, University of Jeddah, Saudi ArabiaView further author information
&
Nabih A. Baeshenb Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Saudi ArabiaORCID Iconhttps://orcid.org/0000-0001-7359-1874View further author information
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Pages 68-74 | Received 09 Dec 2021, Accepted 22 Feb 2022, Published online: 21 Mar 2022

Figures & data

Figure 1. Half-maximal cytotoxic concentration (CC50) and half-maximal inhibitory concentration (IC50) of various R. stricta plant extracts against Vero E6 cells and SARS-CoV-2-infected Vero E6 cells, respectively. The graphs on the left (a, c, e and g) show the CC50 of various plant extracts. Vero E6 cells were treated with various concentrations of the extracts. Cell viability was examined by using a crystal violet assay. Absorbance was measured at λmax 570 nm. The graphs on the right (b, d, f, and h) show the IC50 against SARS-CoV-2 infected Vero E6 cells. The CC50 and IC50 values were calculated using non-linear regression analysis of GraphPad Prism.

Figure 1. Half-maximal cytotoxic concentration (CC50) and half-maximal inhibitory concentration (IC50) of various R. stricta plant extracts against Vero E6 cells and SARS-CoV-2-infected Vero E6 cells, respectively. The graphs on the left (a, c, e and g) show the CC50 of various plant extracts. Vero E6 cells were treated with various concentrations of the extracts. Cell viability was examined by using a crystal violet assay. Absorbance was measured at λmax 570 nm. The graphs on the right (b, d, f, and h) show the IC50 against SARS-CoV-2 infected Vero E6 cells. The CC50 and IC50 values were calculated using non-linear regression analysis of GraphPad Prism.

Data availability statement

The authors confirm that the data supporting the findings of this study are available within the article.

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