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Research Article

Adequate effectiveness of ribociclib plus letrozole or fulvestrant in patients with advanced or metastatic hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer treated in routine Bulgarian clinical practice

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Article: 2268753 | Received 14 Aug 2023, Accepted 04 Oct 2023, Published online: 19 Oct 2023

Figures & data

Figure 1. Progression-free survival – RWE cohort vs. MONALEESA-2 (17). (A) Kaplan–Meier estimates. The tick marks represent censored patients; the shaded area represents 95% CI. (B) Weight-adjusted hazard ratio, ribociclib + letrozole (n = 189) vs. letrozole monotherapy (n = 118). Drug: ribocilib + letrozole; Baseline: letrozole monotherapy; ECOG: Eastern Cooperative Oncology Group; ER: estrogen receptor; PR: progesterone receptor; +: positive; −: negative.

Figure 1. Progression-free survival – RWE cohort vs. MONALEESA-2 (17). (A) Kaplan–Meier estimates. The tick marks represent censored patients; the shaded area represents 95% CI. (B) Weight-adjusted hazard ratio, ribociclib + letrozole (n = 189) vs. letrozole monotherapy (n = 118). Drug: ribocilib + letrozole; Baseline: letrozole monotherapy; ECOG: Eastern Cooperative Oncology Group; ER: estrogen receptor; PR: progesterone receptor; +: positive; −: negative.

Figure 2. Progression-free survival – RWE cohort vs. MONALEESA-3 (19). (A) Kaplan–Meier estimates. The tick marks represent censored patients; the shaded area represents 95% CI. (B) Weight-adjusted hazard ratio, ribociclib + fulvestrant (n = 123) vs. fulvestrant monotherapy (n = 82). Drug: ribocilib + fulvestrant; Baseline: fulvestrant monotherapy; ECOG: Eastern Cooperative Oncology Group; ER: estrogen receptor; PR: progesterone receptor; +: positive; −: negative.

Figure 2. Progression-free survival – RWE cohort vs. MONALEESA-3 (19). (A) Kaplan–Meier estimates. The tick marks represent censored patients; the shaded area represents 95% CI. (B) Weight-adjusted hazard ratio, ribociclib + fulvestrant (n = 123) vs. fulvestrant monotherapy (n = 82). Drug: ribocilib + fulvestrant; Baseline: fulvestrant monotherapy; ECOG: Eastern Cooperative Oncology Group; ER: estrogen receptor; PR: progesterone receptor; +: positive; −: negative.

Figure 3. Overall survival – estimates. (A) RWE cohort vs. MONALEESA-2 (18). (B) RWE cohort vs. MONALEESA-3 (20). The tick marks represent censored patients; the shaded area represents 95% CI.

Figure 3. Overall survival – estimates. (A) RWE cohort vs. MONALEESA-2 (18). (B) RWE cohort vs. MONALEESA-3 (20). The tick marks represent censored patients; the shaded area represents 95% CI.
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Data availability statement

Qualified researchers may obtain anonymized data from this study from the corresponding author upon reasonable request.