West Nile virus meningoencephalitis and cytokines analysis: review and case report

Figures & data

Table 1. Blood tests during hospitalization.

Parameters	Day 1	Day 7	Day 20	Reference range
Hemoglobin, g/L	127	135	134	140-180
WBC, ×10^9/L	6.98^a	13.3	12.58	3.5-10.5
Platelets, ×10^9/L	123	282	214	140-440
C-reactive protein, mg/L	135	19	21	0-10
Albumin, g/L	32	35	30	35-55
Creatinine, µmol/L	157	129	100	74-134
Urea, mmol/L	11	12.2	7	3.2-8.2
Aspartate transaminase, U/L	62	32	22	0-36
Alanine transaminase, U/L	59	35	33	0-49
Sodium, mmol/L	137	159	131	136-151
Potassium, mmol/L	3.4	4.7	4.1	3.5-5.6
Fibrinogen	5.55	–	4.72	2-4.5
Prothrombin time, %	118	120	–	> 70
Thrombin time, sec	18.4	–	–	14-21

WBC-white blood cells.

^a77.6% polymorphonuclear cells, 10.3% monocytes, 8.3% lymphocytes and 3.7% basophils.

Table 2. CSF analysis on admission (on day 1) and control LPs (on days 7 and 17).

Parameters	1st LP (day 1)	2nd LP (day 7)	3rd LP (day 17)	Reference range
WBC, ×10^6/L	106	3	6	<6
Protein, g/L	2.26	0.72	0.43	<0.45
Glucose, mmol/L	2.2	4.1	3.3	2.22–4.44
Serum glucose, mmol/L	5.8	7.4	3.9	2.8–6.1

WBC-white blood cells.

Table 3. Cytokines levels in CSF and serum specimen.

Cytokines	CSF pg/mL	Serum pg/mL
IL-6	214.8	53
IL-8	18.8	2347.6
IL-10	119.3	128.5
IL-12 (p40)	136.6	361.9
TNF-α	0	0

Figure 1. Control CT of the brain. No pathological changes in the parenchyma. Presence of anatomic variation (smaller left sinus transverses).

Figure 2. Chest radiography. Inflammatory pneumonitis in the right basal lung. Hypoventilated surrounding parenchyma. Cardiac shadow with elongated left ventricular arch.

Figure 3. Brain MRI transverse and coronal plane.

Data availability statement

The anonymized raw clinical and laboratory data associated with the present report are available from the corresponding author [P.A.] upon a reasonable request.