Alteration of thiol-disulphide homeostasis in acute tonsillopharyngitis

Figures & data

Table 1 The laboratory values of the patients and control children

	Viral tonsillopharyngitis (n = 73)	Bacterial tonsillopharyngitis (n = 21)	Control children (n = 88)
CRP values^# [Median (min–max)]	19.1 (0.5–212)^a,b	40.4 (7.0–264.1)^b	2.9 (0.5–11.4)
White blood cell counts* [Median (min–max)]	10.9 (3.2–29.4)^b,c	16.0 (9.3–25.1)^b	7.9 (3.4–13.0)

min, minimum; max, maximum.

* In thousands.

# Normal values range between 0 and 5 mg/dl.

^aP = 0.014 compared with bacterial tonsillopharyngitis.

^bP < 0.001 compared with control.

^cP < 0.001 compared with bacterial tonsillopharyngitis.

Figure 1 Native thiol levels by infection type. Control children had higher native thiol values than both viral and bacterial tonsillopharyngitis patients.

Figure 2 Disulphide levels by infection type. Viral tonsillopharyngitis patients had higher serum disulphide levels than bacterial tonsillopharyngitis patients.

Figure 3 Disulphide/native thiol ratios by infection type. The disulphide/native thiol ratio was higher in the viral and bacterial tonsillopharyngitis patients than in the control children.

Table 2 Spearman's correlation analysis of native thiol, total thiol, and disulphide values

Parameter	Native thiol		Total thiol		Disulphide
	r value	P value	r value	P value	r value	P value
CRP	−0.264	<0.001*	−0.266	<0.001*	0.043	0.56
WBC	−0.228	0.002*	−0.191	0.01*	0.160	0.03*

CRP, C-reactive protein; WBC, white blood cell count.

* Statistically significant.