Relevance of oxidative stress biomarkers, hemoglobin A1c, troponin-I, and angiotensin-converting enzyme metabolism to blood pressure in acute myocardial infarction: a case-control study

Figures & data

Table 1. The characteristics of selected parameters of AMI patients and controls.

	AMI Patients (n = 306)	Controls (n = 410)	P
Mean age (years)	64 [35–103]	63[35–87]	0.085
Sex (male/female)	163/143	228/182	0.292
Smoking, n (%)	220(71.9)	75(18.3)	<0.001
BMI (kg/m^2)	28.2[18–46.2]	26.8[15.4–40.8]	<0.001
Fasting glucose (mmol/L)	6.5[3.8–9.83]	5[4–6.70]	<0.001
HbA1c (%)	6[3.2–15.5]	5 [3–6.7]	<0.001
Total cholesterol (mmol/L)	8.4[5–14.5]	4.1[1–5.7	<0.001
LDL-C (mmol/L)	5.97[2.6–9.4]	2.5[2–4.5]	<0.001
HDL-C (mmol/L)	2[0.8–2.8]	1[0.9–2]	<0.001
Triglycerides(mmol/L)	2[1–6.8]	1.2[0.5–2]	<0.001
DBP(mm Hg)	96[62–196]	83[65–99]	<0.001
SBP (mm Hg)	155[65–226]	129[85–155]	<0.001
HR(bpm)	80[40–160]	78[59–89]	0.013
RPP(mm Hg. Bpm)	12220[4680–31840]	9933[6035–13020]	<0.001
Serum ACE activity (U/L)	97.8[25–219.5]	88[20.44–145]	<0.001
Peak-cTnI (mg/l)	45.7[30–49.8]	0[0–0.1]	<0.001
LDH (mg/l)	643[174–9510]	289[117–432]	<0.001
CPK (mg/l)	730[26–9390]	34[4–1888]	<0.001
CRP (mg/l)	7[2–77]	3[1–9]	<0.001

BMI: Body Mass Index; HR: Heart Rate; RPP: Rate pressure product; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; SBP: Systolic Blood Pressure; DBP: Diastolic Blood Pressure; Creatine phosphokinase: CPK; Reactive protein C: CRP; Lactate dehydrogenase: LDH; cTnI: cardiac troponin T.

Table 2. Malondialdehyde (MDA), conjugated dienes (CD) levels and GPx activity in plasma of controls and AMI patients.

	AMI Patients (n = 306)	Controls (n = 410)	P
CD (µmol of hydroperoxyde/mg of protein)	199[49–917]	88[20.4–356]	<0.001
MDA (nmol/mg of protein)	0.49[0.08–0.94]	0.24[0.09–0.94]	<0.001
GPx (mg/mL/mg of protein)	20.94[12.2–59.8]	50.96[14.7–81.6]	<0.001

MDA: Malondialdehyde; CD: Conjugated Diene; GPx: Glutathione Peroxidase.

Figure 1. Scatterplot illustrating the correlation between cTnI and (a) MDA (r = 0.569; p = 0.001); (b) DC (r = 0.845; p = 0.001); (c) GPx (r = −0. 0.982; p = 0.001); (d) HbA1c (r = 244; p = 0.001) in AMI patients.

Figure 2. Scatterplot illustrating the Pearson's correlation between (a) HbA1c and Serum ACE activity (r = 0.320; p = 0.001); (b) HbA1c and RPP (r = 0.258; p = 0.001) in AMI patients.

Author contributions

R. Chaaba: Conception and design, S. Hammami: acquisition and analysis ofdata, S. Mehri and J. Finsterer: writing, review, and/or revision of the manuscript, M. Hammami: study supervision, All authors have read and agreed to the published version of the manuscript.

Data availability statement

The authors confirm that data presented in this study are available in article.