Investigation of serum ischemic-modified albumin, galectin-3, paraoxonase-1, and myeloperoxidase activity levels in patients with acute brucellosis

Figures & data

Table 1. The demographic values of the brucellosis group and control group.

		Control group	Patient group	p
Gender	Female	20 (50,0%)	19 (47,5%)
	Male	20 (50,0%)	21 (52,5%)
BMI (kg/m^2)		22,32 ± 1,54	22,21 ± 1,38	0,342
Age (Year)		33,20 ± 7,90	33,00 ± 7,78	0,962

Note: Data are expressed as mean ± SD (standart deviation), BMI: Body mass index.

Figure 1. Serum Gal-3, IMA, MPO, and PON1 levels in the brucellosis group and control group.

Table 2. Serum IMA, Gal-3, PON-1, and MPO levels in the brucellosis group and control group.

Parameters	Controlgroup	Patientgroup	95% confidence interval of the difference	p
			Lower -Upper
IMA (ng/ml)	149,16 ± 93,10	217,52 ± 150,40*	12,67–124,04	0,017
Gal-3 (pg/ml)	408,28 ± 159,74	711,56 ± 621,50*	101,28–505,27	0,005
PON-1 (ng/ml)	220,30 ± 146,37	141,25 ± 64,59 *	28,68–129,40	0,003
MPO (ng/ml)	22,62 ± 12,85	30,86 ± 15,02*	2,01–14,46	0,010

Notes: Data are expressed as mean ± SD (standart deviation), p < 0.01* the degree of significance of comparison between the patient and control group.

Abbrevations: IMA: Ischemic modified albumin:, gal-3: galectin-3, PON-1: paraoxonase-1, and MPO: myeloperoxidase.

Table 3. The relationship between measuring parameters in patient group with Spearman correlation.

Parameters		BMI	Age	Gal-3	IMA	MPO	PON-1
BMI	r	1
	p
Age	r	0,012	1
	p	0,941
Gal-3	r	0,111	0,181	1
	p	0,493	0,263
IMA	r	0,155	0,235	0,927**	1
	p	0,339	0,144	0,000
MPO	r	0,322*	0,119	0,683**	0,707**	1
	p	0,043	0,464	0,000	0,000
PON-1	r	0,096	0,209	−0,951**	−0,943**	−0,731**	1
	p	0,557	0,195	0,000	0,000	0,000

Note: p < 0.01* *, p < 0.05*.

Abbrevations: BMI: Body mass index, IMA: Ischemic modified albümin:, gal-3: galectin-3, PON-1: paraoxonase-1, and MPO: myeloperoxidase.

Figure 2. The ROC curve analysis of IMA, Gal-3, PON-1, and MPO for prediction between the frequently control group between in patients with brucellosis. Abbrevations: IMA: Ischemic modified albumin, gal-3: galectin-3, PON-1: paraoxonase-1, and MPO: myeloperoxidase.

Data availability statement

The data presented in this study are available upon request from the corresponding author.Is Previously Presented? This study was previously presented as oral presentation. (TBS INTERNATIONAL BIOCHEMISTRY CONGRESS 2022 33rd NATIONAL BIOCHEMISTRY CONGRESS, 26-30 OCTOBER 2022, İZMİR, TURKEY)