miRNAs as potential therapeutic targets and diagnostic biomarkers for cardiovascular disease with a particular focus on WO2010091204

ABSTRACT

Introduction: A number of miRNAs have been reported to be critically involved in the regulation of cardiovascular disease (CVDs). Therefore, the development of potent analogues/inhibitors for miRNAs have thus become a key focus in the present drug discovery. In this review, we discuss the basic research and clinical use of miRNAs as the early diagnosis and therapeutic targets for CVD. We have also focused on the efficiency of therapeutically targeting miR-499, which is considered as one of the most promising molecules for treating CVDs.

Areas covered: In this review, we have discussed the patents and patent applications related to miRNAs detected in CVD patients published in recent years. This review also covers the expression pattern of miR-499, as well as it highlights functions of its inhibitors in CVD. We used Google and Pubmed search engines to find relevant patents.

Expert opinion: Although a massive number of miRNAs are patented as CVD biomarkers, further work is absolutely required to evaluate the reliable diagnostic values and therapeutic potential of these candidates. Overall, targeting miRNAs is definitely a promising strategy to be investigated for diagnosis and treatment of CVDs in future, however, the delivery system and off-targets effects are still a difficult challenge need to be elucidated.

KEYWORDS:

• Mirna
• cardiovascular
• biomarker
• diagnosis
• miR-499
• inhibitors

Article highlights

• In the past two years, more than 100 miRNAs have been detected in the serum of CVD patients and they are patented. We have reviewed in this article.

• Among these miRNAs, we have focused on the biological role and mechanism of action of miR-499, which is one of the most promising molecules in cardiobiology.

• The development of miRNA analogues/inhibitors and problems associated with their efficacy are comprehensively illustrated.

This box summarizes key points contained in the article.

Declaration of interest

The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Additional information

Funding

This work was supported by National Natural Science Foundation of China (31430041; 81230005); China Postdoctoral Science Foundation (2016M590616), (2017M612189) and Doctoral foundation of Shandong province (201601016).