Abstract
Objective: Few studies have investigated haem oxygenase-1 gene (HMOX1) promoter polymorphism in microvascular angina (MVA).
Materials and methods: HMOX1 promoter (GT)n repeats were examined in healthy controls (N = 220) and MVA subjects (N = 181).
Results: The distribution of genotype of SS, SL and LL were significantly different in MVA (17%, 51%, 33%) vs. normal controls (35%, 46%, 20%) (p < 0.001, S allele: ≤30 repeats, L allele: >30 repeats). In multivariate analysis, carrier of L allele (odds ratio 2.772, p < 0.001) was a significant predictor for the diagnosis of MVA.
Conclusions: Subjects with MVA had longer HMOX1 promoter (GT)n repeats than the healthy controls.
Trial registration number: NCT01198730 at https://clinicaltrials.gov
Acknowledgements
The authors thank the Biostatistics Task Force of Taichung Veterans General Hospital for statistical support.
Disclosure statement
No potential conflict of interest was reported by the authors.