Cabbage juice protect against lead-induced liver and kidney damage in male Wistar rat

Abstract

Aim

Liver and kidney has been implicated in Lead toxicity and this has been linked to oxidative damage. On the other hand, cabbage is one of the widely consumed vegetables with a plethora of health benefits. This present study investigated the protective effect of cabbage juice on lead-induced toxicity in male Wistar rats.

Methods

Twenty male Wistar rats were randomly divided into four groups (n = 5) and were treated with distilled water (1 ml/100 g b.wt), Lead acetate (25 mg/kg b.wt), cabbage juice (1 ml/100 g b.wt) and Lead acetate plus cabbage juice respectively. All treatments were administered orally for 28 days. Following euthanasia, blood was collected and serum decanted for biochemical assay and liver and kidney tissues were harvested, prepared for antioxidant activity and histological study.

Result

Cabbage juice significantly attenuated Lead-induced liver and kidney dysfunction by lowering serum concentrations of urea, creatinine, ALP, AST and ALT. Antioxidants (SOD, CAT, GSH) were also upregulated in liver and kidney tissues. Cabbage juice restored the histoarchitectural changes caused by lead intoxication.

Conclusion

Cabbage juice consumption protected the liver and kidney against lead-induced toxicity by enhancing in vivo anti-oxidant defense system.

Keywords:

• Cabbage juice
• lead acetate
• liver enzymes
• kidney function
• antioxidants

Correction Statement

This article has been corrected with minor changes. These changes do not impact the academic content of the article.

Acknowledgements

The authors would like to thank Miss. Dagogo Gwendolin, Mr. Kingsley Etim and Mr. Inegbenehi Saviour for their assistance during the experiment. We equally thank the management of PAMO University of Medical Sciences for providing the experimental animals.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

Data are available on request.