Effect of propranolol on verbal problem solving in autism spectrum disorder

Abstract

The noradrenergic system modulates performance on tasks dependent on semantic and associative network flexibility (NF) in individuals without neurodevelopmental diagnoses in experiments using a beta-adrenergic antagonist, propranolol. Some studies suggest drugs decreasing noradrenergic activity are beneficial in ASD. In individuals without neurodevelopmental diagnoses, propranolol is beneficial only for difficult NF-dependent problems. However, in populations with altered noradrenergic regulation, propranolol also benefits performance for simple problems. Due to decreased flexibility of access to networks in ASD, we wished to examine the effect of propranolol on NF in ASD. ASD subjects benefited from propranolol on simple anagrams, whereas control subjects were impaired by propranolol. Further study will be necessary to confirm this finding in a larger sample and to compare clinical response with cognitive response to propranolol.

Keywords:

• Autism
• Asperger syndrome
• Noradrenergic
• Semantic
• Language
• Problem solving
• Propranolol

This research was funded by NINDS (K23 NS43222-Beversdorf) and a pilot grant from NAAR (National Alliance for Autism Research).