Selective IGT decision-making impairment in a patient with juvenile Parkinson's disease and pathological gambling: A role for dopaminergic therapy?

Abstract

The orbitofrontal cortex and the dopaminergic system are structures involved in managing impulsivity and sensibility to reinforcements, and both are typically impaired in Parkinson's disease (PD). Also, l-DOPA treatment can contribute to the development of the ‘Dopamine Dysregulation Syndrome’, a syndrome that can influence the patients' personality and lead to risk-taking behaviors. In this study, we describe the case of a 42-year-old woman (LT) affected by juvenile PD, treated with both l-DOPA and dopamine agonists, who showed a sudden onset of pathological gambling (PG), as the only neuropsychiatric symptom. We assessed LT with a full neuropsychological battery and the Iowa Gambling Task (IGT), in order to describe her specific failure in decision making. LT's performance on the IGT is compared with that of 15 non-demented PD patients under therapy with dopamine agonists and no behavioral dysregulations and with that of 16 age- and education-matched healthy subjects. Results showed fully preserved memory, executive functions, and reasoning abilities for LT, but a remarkable and stable impairment in the IGT. Performance of LT on the IGT is significantly lower than that of both control groups. This case shows, for the first time, that high cognitive functioning and preserved executive functions are no guarantee for advantageous decision making, and that the onset of PG is consistent with selective orbitofrontal disruption and side-effects of dopamine agonist therapy. It is also showed that the IGT is a useful neuropsychological device to detect specific risk-taking behaviors, which compromise functioning in real life.

Keywords:

• Pathological gambling
• Parkinson's disease
• Iowa Gambling Task
• Dopamine
• Neuropsychological assessment
• Executive functions
• Decision making

Acknowledgments

L.Z. receives research support from FWF, Austrian Science Fund, Project-Nr. P21636-B18. J.W. receives research support from Leopold-Franzens University Innsbruck (Doktoratsstipendium).

Notes

¹Previous studies with healthy individuals have found age-related effects in performance on the IGT (Fein, McGillivray, & Finn, 2007; Zamarian, Sinz, Bonatti, Gamboz, & Delazer, 2008), with the healthy older individuals deciding on average less advantageously than the healthy younger individuals. Although in this study the PD control group was slightly older than patient LT, control patients performed significantly better than LT.