ABSTRACT
Despite a well-documented pattern of semantic impairment, the patterns of brain activation during semantic processing in semantic variant primary progressive aphasia (svPPA) still remain poorly understood. In the current study, one svPPA patient (EC) and six elderly controls carried out a general-level semantic categorization task while their brain activity was recorded using magnetoencephalography (MEG). Despite similar behavioral performance, EC showed hyperactivation of the left inferior temporal gyrus (ITG) and right anterior temporal lobe (ATL) relative to controls. This suggests that periatrophic regions within the ATL region may support preserved semantic abilities in svPPA.
Disclosure statement
The authors declare they have no actual or potential conflicts of interest that could prejudice or bias the results and outcomes reported in this manuscript.
Notes
1. A significance statistical threshold of p > .001 uncorrected was used for the VBM analyses.
2. Peaks of hyperactivation in EC relative to the control group. A significance statistical threshold at q ≤ .05 FDR has been used. Talairach (MNI) coordinates are provided.
3. Peaks of hyperactivation for the crossover interaction. A significance statistical threshold at q ≤ .05 FDR has been used.