Lack of an association between left-handedness and APOE polymorphism in a large sample of adults: Results of the Czech HAPIEE study

Figures & data

TABLE 1 Distribution of left-handers among the different APOE genotypes

	Self-reported hand preference for writing		Higher grip strength
	Right-handers	Left-handers	Right hand	Left hand
APOE	N (%)	N (%)	N (%)	N (%)
E2E2	28 (93.3)	2 (6.7)	26 (86.7)	4 (13.3)
E2E3	495 (95.4)	24 (4.6)	456 (87.9)	63 (12.1)
E3E3	2,780 (94.9)	151 (5.1)	2,573 (87.8)	358 (12.2)
E4E3	794 (95.8)	35 (4.2)	730 (88.1)	99 (11.9)
E4E2	85 (95.5)	4 (4.5)	73 (82.0)	16 (18.0)
E4E4	42 (97.7)	1 (2.3)	40 (93.0)	3 (7.0)
	p=.828		p=.557

TABLE 2 Odds ratios

	Grip stronger in left hand				Grip stronger in left hand
	APOE2 vs APOE33 (N=3447)		APOE2 vs APOE43/44 (N=1411)		APOE2 vs APOE33 (N=3447)		APOE2 vs APOE43/44 (N=1411)
	OR (95%CI)	p-value	OR (95%CI)	p-value	OR (95%CI)	p-value	OR (95%CI)	p-value
All age groups*	0.92 (0.60–1.41)	0.691	1.16 (0.69–1.95)	0.995	0.96 (0.72–1.27)	0.771	1.01 (0.72–1.41)	0.966
45–49 years	0.78 (0.29–2.04)	0.608	1.07 (0.33–3.49)	0.909	0.91 (0.44–1.85)	0.789	0.86 (0.38–1.98)	0.731
50–54 years	0.80 (0.28–2.33)	0.685	1.10 (0.30–4.00)	0.884	1.08 (0.58–2.00)	0.808	1.06 (0.51–2.18)	0.885
55–59 years	1.16 (0.43–3.12)	0.770	1.57 (0.44–5.55)	0.485	0.91 (0.48–1.75)	0.781	0.82 (0.39–1.74)	0.606
60–64 years	1.48 (0.66–3.31)	0.340	1.63 (0.59–4.44)	0.343	0.91 (0.51–1.62)	0.742	1.45 (0.70–3.02)	0.317
65–69 years	0.55 (0.19–1.57)	0.264	0.68 (0.21–2.22)	0.521	1.00 (0.53–1.86)	0.991	0.93 (0.45–1.40)	0.834
p for heterogeneity	0.615		0.825		0.994		0.837
Men	0.79 (0.40–1.54)	0.484	0.75 (0.35–1.62)	0.472	0.97 (0.65–1.48)	0.915	0.95 (0.59–1.53)	0.882
Women	1.03 (0.59–1.79)	0.915	1.78 (0.86–3.70)	0.122	1.00 (0.68–1.47)	0.992	1.13 (0.72–1.79)	0.587
p for heterogeneity	0.540		0.108		0.932		0.591

Age-sex-adjusted and age-specific odds ratios of left-handedness by presence of APOE2 allele, with confidence intervals and p-values. Left-handedness was the dependent variables coded as 0 (non-left-handed) and 1 (left-handed); the presence of APOE2 allele was coded as 0 (no APOE2 allele present) and 1 (at least one APOE2 allele present). *Adjusted for age and sex