Neurophysiological basis of manual force asymmetries in young and senior adults

ABSTRACT

In this study, we investigated age differences in manual force production to explore their neurophysiological basis. Manual pinching and gripping forces were first measured during unilateral and bilateral efforts in two groups of right-handed adults (young, n = 12, senior, n = 11). Then, transcranial magnetic stimulation (TMS) was applied to each hemisphere to assess central motor inhibition via the contralateral and ipsilateral silent period (cSP, iSP). Laterality quotients (LQs) were computed to determine asymmetries for unimanual strength tests and hemispheric asymmetries in TMS measures. Bilateral indices (BLI) were computed to assess the bilateral force deficit (BFD). During unilateral efforts, both young and senior participants exhibited similar degrees of asymmetry. Similarly, no age difference was detected when comparing LQs derived from TMS measures. During bilateral efforts, although BLI tended to be lower in seniors, no age difference was detected. Asymmetry in strength and BLI showed no association with hemispheric asymmetry in TMS measures, except for the asymmetry in pinch strength, which was associated with asymmetry in the iSP duration. These observations confirm that asymmetries in manual strength and BFD are little affected by age. Also, our results show that hemispheric asymmetries in transcallosal inhibition are associated with pinch strength asymmetry.

KEYWORDS:

• Strength asymmetry
• bilateral deficit
• transcranial magnetic stimulation
• silent period
• ageing

Acknowledgments

The authors wish to thank all participants for their time and patience during testing. Special thanks to Anthony Remaud PhD for technical assistance with data collection and data analysis. This work served as partial fulfilment towards an MSc degree in Human Kinetics by JH.

Disclosure statement

No potential conflict of interest was reported by the author(s).