Cobalamin in inflammation III — glutathionylcobalamin and methylcobalamin/adenosylcobalamin coenzymes: the sword in the stone? How cobalamin may directly regulate the nitric oxide synthases

Figures & data

Figure 1 Human neuronal(nNOS), endothelial (eNOS) and inducible nitric oxide synthase (iNOS) domain structure (PDZ domain, named after homologous domains in three proteins: PSD‐95, DH/g, ZO‐1).

Figure 2 Model of nitric oxide synthase oxygenase(NOSox) dimer with approximate scheme for hypothetical glutathionylcobalamin (GSCbl) links in relation to the two hemes, ZnS₄, BH₄, arginine. Ser 104 is in the loop with the Cys ligands and H bonds to the C6 side chain of BH₄.