Subtraction technique on ¹⁸F-fluoro-2-deoxy-d-glucose positron emission tomography (¹⁸F-FDG-PET) images

Figures & data

Table. 1. Current clinical applications of ¹⁸F-FDG-FET subtraction techniques.

Functions	Applications of ^18F-FDG-PET subtraction techniques
Distinguishing	Primary glioma recurrence from radiation necrosis [19] More accurate identification of seizure lateralization and the potential effects of treatment [20] Osteomyelitis and indolent inflammation [21]
Evaluation	Patients with suspected glioma recurrence [19] Chemotherapy results of cancer patients [22] Efficacy of pharmacotherapy [23] Impact of doxorubicin, bleomycin, vinblastine and dacarbazine chemotherapy on brain metabolism [24] Amount of bone loss [25] Prognostic significance in patients with diffuse large B-cell lymphoma receiving rituximab-containing chemotherapy [26]
Background correction	Internal carotid artery with atherosclerotic stenosis ≥70% [27] Differentiating tumours from inflammation [28]

Figure 1. Image subtraction procedures.

Figure 2. An example of image normalization.

Figure 3. Nine potential situations of registration transformation.

Figure 4. The scan image after registration.

Figure 5. The ¹⁸F-FDG-PET data before and after treatment.

Figure 6. The normalization (a) and registration (b) images before and after treatment, with the anterior cortex used as the reference.

Figure 7. The normalization (a) and registration (b) images before and after treatment, with the posterior cortex used as the reference.

Figure 8. The subtraction result rendered at a cut-off of 0.1 (blue colour indicates the previous abnormal metabolic state).

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