Treatment with human chorionic gonadotropin for PADAM: A preliminary report

Figures & data

Table I.  Production of testosterone in response to intramuscular injection of 10,000 IU of hCG.

Before (ng/ml)	4 days later (ng/ml)	response (times)
1.3 ± 0.5	4.3 ± 1.8	3.4 ± 1.4

Table II.  Endocrinologic values before and after HRT in patients who received hCG injections.

	Normal range	Pre-HRT	Post-HRT	P
TT (ng/ml)	2.7–10.7	2.1 ± 0.5	2.7 ± 0.7	<0.01
cFT (pg/ml)	–	52.7 ± 13.2	65.4 ± 22.3	<0.05
cBT (ng/ml)	–	1.2 ± 0.3	1.5 ± 0.5	<0.05
E2 (pg/ml)	20–60	28.9 ± 11.0	28.5 ± 11.9	NS
LH (mIU/l)	1.7–11.2	4.0 ± 2.4	4.2 ± 3.1	NS
FSH (mIU/l)	2.1–18.6	10.7 ± 9.5	9.6 ± 9.3	NS
PRL (ng/ml)	0–15	16.9 ± 18.2	12.1 ± 15.2	<0.05
GH (ng/ml)	–	0.3 ± 0.3	0.4 ± 0.5	NS
IGF-1 (ng/ml)	59–215	212.6 ± 37.3	206.1 ± 44.1	NS
uDP (nmol)	2.1–5.4	3.8 ± 1.2	3.8 ± 1.2	NS

HRT, hormone replacement therapy; TT, total testosterone; cFT, calculated free testosterone; cBT, calculated bioavailable testosterone; E2, estradiol; LH, luteinizing hormone; FSH, follicle-stimulating hormone; PRL, prolactin; GH, growth hormone; IGF-1, insulin-like growth factor-1; uDP, urinary deoxypyridinoline. NS, not significant. P value calculated by paired Student's t-test.

Table III.  PADAM symptom scores before and after HRT in patients who received hCG injections.

	Pre-HRT	Post-HRT	P
AMS score	53.6 ± 9.4	42.1 ± 11.0	<0.01
psychological	15.0 ± 3.9	10.6 ± 4.1	<0.01
somatovegetative	22.7 ± 4.7	17.6 ± 5.1	<0.01
sexual	16.0 ± 2.9	14.0 ± 3.6	<0.05
IIEF-5 score	9.2 ± 6.3	10.2 ± 7.2	NS
SDS score	48.5 ± 7.3	42.6 ± 10.7	NS

HRT, hormone replacement therapy; AMS, Aging Males' Symptoms; IIEF-5, International Index of Erectile Function; SDS, Self-rating Depression Scale. NS, not significant. P value calculated by paired Student's t-test.

Table IV.  Laboratory values before and after HRT in patients who received hCG injections.

	Normal range	Pre-HRT	Post-HRT	P
RBC (x10^6/ml)	440–560	461.3 ± 24.9	476.0 ± 34.3	<0.05
Hb (g/dl)	13.8–17.0	14.4 ± 0.5	14.8 ± 0.8	<0.05
Ht (%)	41–51	42.5 ± 1.6	43.9 ± 2.4	<0.01
AST (U/l)	0–30	16.0 ± 4.7	17.6 ± 6.1	NS
ALT (U/l)	0–32	17.0 ± 4.9	21.2 ± 14.6	NS
γ-GTP (mIU/l)	9–51	37.1 ± 33.1	39.0 ± 38.4	NS
Total cholesterol (mg/dl)	150–220	207.7 ± 31.2	208.4 ± 33.8	NS
HDL cholesterol (mg/dl)	40–80	58.9 ± 40.0	51.2 ± 10.4	NS
triglyceride	30–150	236.8 ± 161.7	246.9 ± 155.4	NS
PSA (ng/dl)	0.0–2.1	1.1 ± 0.7	1.2 ± 0.8	NS

HRT, hormone replacement therapy; RBC, red blood cell; Hb, hemoglobin; Ht, hematocrit; AST, aspartate amino transferase; ALT, amino alanine transferase; γ-GTP, gamma glutamyl transpeptidase; PSA, prostate specific antigen. NS, not significant. P value calculated by paired Student's t-test.