Decline of serum levels of free testosterone in aging healthy Chinese men

Figures & data

Table I.  Age-related change of serum sex hormones expressed by median (n).

	20 Age (yrs)	40 Age (yrs)	50 Age (yrs)	60 Age (yrs)	70 Age (yrs)	K_W Age (yrs)	p
LH (IU/L)	3.10 (175)	3.85 (92)	4.00 (218)	4.50 (185)	6.60 (192)	156.04	0.0000
FSH (IU/L)	3.30 (171)	5.30 (89)	6.80 (218)	8.30 (179)	13.30 (178)	319.91	0.0000
T (nmol/L)	19.83 (180)	21.58 (95)	20.20 (222)	20.96 (189)	20.77 (192)	4.78	0.3103
CFT (nmol/L)	0.44 (199)	0.41 (95)	0.37 (222)	0.35 (188)	0.30 (192)	140.52	0.0000
E2 (pmol/L)	90.42 (172)	112.91 (86)	110.17 (210)	115.84 (176)	114.38 (186)	30.61	0.0000
SHBG (nmol/L)	32.15 (162)	43.30 (77)	44.20 (197)	47.90 (169)	54.40 (152)	137.29	0.0000
TSI (T/LH)	6.55	6.02	4.62	4.61	3.28	96.74	0.0000
FTI (T/SHBG)	0.64	0.55	0.44	0.43	0.37	234.20	0.0000
T/E2	0.21	0.18	0.19	0.18	0.18	10.00	0.0404

Table II.  Spearman's analysis for the relation between androgen and aging.

	Age	BMI (kg/m^2)	WHR	LH (IU/L)	FSH (IU/L)
T (nmol/L)
r =	0.0496	−0.1516	−0.0553	0.0163	0.0508
P =	0.1716	0.0001	0.1681	0.6484	0.1644
n =	793	621	622	779	752
CFT (nmol/L)
r =	−0.4348	−0.0435	−0.1504	−0.2704	−0.3785
P =	< 0.0001	0.3187	0.0005	< 0.0001	< 0.0001
n =	648	528	530	675	660
SHBG (nmol/L)
r =	0.4239	−0.1623	0.0844	0.3230	0.3782
P =	< 0.0001	0.0002	0.0520	< 0.0001	< 0.0001
n =	640	529	531	676	661
TSI
r =	−0.3407	0.0017	0.0126	−0.8106	−0.4963
P =	< 0.0001	0.9667	0.7575	< 0.0001	< 0.0001
n =	748	607	608	779	748
FTI
r =	−0.5250	0.0603	−0.3432	−0.3462	−0.4579

Table III.  The 10th and 90th percentiles for t, cFT, TSI, and FTI.

	T (nmol/L)	CFT (nmol/L)	TSI	FTI
	10	10	10	10
Age (yrs)	90	90	90	90
20∼	11.485	0.297	2.804	0.416
	27.725	0.608	12.429	0.976
40∼	8.779	0.286	1.795	0.359
	32.930	0.587	11.299	0.940
50∼	11.434	0.225	1.495	0.296
	29.529	0.493	10.261	0.724
60∼	13.880	0.215	1.317	0.290
	31.334	0.482	9.738	0.623
70∼	12.353	0.190	1.182	0.253
	30.987	0.404	6.704	0.503

Table IV.  The rate of decline for cFT, TSI, and FTI, expressed as median.

Age (yrs)	cFT	TSI	FTI
20∼	100	100	100
40∼	97.18 (−2.82)	91.91 (−8.09)	85.96 (−14.04)
50∼	80.47 (−19.53)	70.55 (−29.45)	68.64 (−31.36)
60∼	77.43 (−22.57)	70.51 (−29.49)	66.08 (−33.92)
70∼	66.81 (−33.19)	50.20 (−49.80)	56.89 (43.11)

Table V.  The relationship between partial androgen deficiency and aging.

	40∼	50∼	60∼	70∼	X^2	p
CFT (nmol/L)	13.04%	31.76%	30.14%	46.67%	57.042	0.0000
TSI	14.46%	23.35%	22.84%	42.20%	54.162	0.0000
FTI	17.39%	40.54%	47.26%	71.11%	129.548	0.0000