The effects of daily alendronate, daily calcitonin and alendronate every other day on bone mineral density in osteoporotic men

Figures & data

Table I.  Demographic characteristics of patients.

	Group 1 (n = 15)	Group 2 (n = 14)	Group 3 (n = 17)
Age (years)	63 ± 11	61 ± 11	65 ± 10
Height (cm)	165 ± 4.8	165 ± 4.9	169 ± 4.6
Weight (kg)	65.6 ± 7.2	64.6 ± 7.3	69.9 ± 8.6
BMD (g/cm^2)
Lumbar (L2–4)	0.89 ± 0.12	0.88 ± 0.18	0.96 ± 0.12
Femoral neck	0.77 ± 0.08	0.78 ± 0.1	0.76 ± 0.1
Ward's triangle	0.63 ± 0.1	0.64 ± 0.12	0.64 ± 0.08

Table II.  Biochemical parameters.

	Group 1 (n = 15)	Group 2 (n = 14)	Group 3 (n = 17)
Glucose (mg/dl)	128 ± 10	134 ± 15	124 ± 8
BUN (mg/dl)	13.8 ± 7	14 ± 2.8	15.3 ± 3.6
Creatinine (mg/dl)	0.7 ± 0.2	0.6 ± 0.1	0.7
AST (U/l)	20.7 ± 5	23 ± 6	21 ± 4
ALT (U/l)	19.7 ± 7.3	20 ± 8.2	20 ± 7
Ca (mg/dl)	9.3 ± 0.3	9.5 ± 0.5	9.6 ± 0.5
P (mg/dl)	3.1 ± 0.3	3.3 ± 0.4	3.1 ± 0.4
ALP (U/l)	234 ± 18	250 ± 24	246 ± 14
Haemoglobin (g/dl)	12.8 ± 3	13 ± 4	13.1 ± 4

Figure 1. Bone mineral density level of lumbar spine.

Table III.  BMD and T score levels in the daily alendronate group.

	Baseline	Sixth month	Twelfth month	p
BMD (g/cm^2)
Lumbar	0.89 ± 0.12	0.9 ± 0.14	0.9 ± 0.15	0.004
Femoral neck	0.7 ± 0.08	0.7 ± 0.09	0.7 ± 0.09	>0.05
Ward's	0.63 ± 0.1	0.6 ± 0.11	0.6 ± 0.11	>0.05
T scores
Lumbar	−2.6 ± 0.9	−2.2 ± 1	−2 ± 1	<0.001
Femoral neck	−2.2 ± 0.5	−2.2 ± 0.8	−2.2 ± 0.9	>0.05
Ward's	−2.3 ± 0.7	−2.3 ± 0.7	−2.2 ± 0.9	>0.05

Table IV.  BMD and T score levels in the every other day alendronate group.

	Baseline	Sixth month	Twelfth month	p
BMD (g/cm^2)
Lumbar	0.88 ± 0.18	0.9 ± 0.14	0.9 ± 0.15	0.001
Femoral neck	0.78 ± 0.1	0.7 ± 0.09	0.7 ± 0.09	>0.05
Ward's	0.64 ± 0.12	0.6 ± 0.11	0.6 ± 0.11	>0.05
T scores
Lumbar	−2.6 ± 0.9	−2.2 ± 1	−2 ± 1	<0.001
Femoral neck	−2.2 ± 0.5	−2.2 ± 0.8	−2.2 ± 0.9	>0.05
Ward's	−2.3 ± 0.7	−2.3 ± 0.7	−2.2 ± 0.9	>0.05

Table V.  BMD and T score levels in calcitonin group.

	Baseline	Sixth month	Twelfth month	p
BMD (g/cm^2)
Lumbar	0.96 ± 0.1	0.97 ± 0.1	1 ± 0.7	0.04
Femoral neck	0.76 ± 0.1	0.77 ± 0.9	0.79 ± 0.9	>0.05
Ward's	0.64 ± 0.08	0.65 ± 0.8	0.68 ± 0.1	0.002
T scores
Lumbar	−2.1 ± 0.9	−1.8 ± 0.9	−1.7 ± 0.7	<0.05
Femoral neck	−2.1 ± 0.5	−2 ± 0.7	−1.9 ± 0.5	>0.05
Ward's	−2.2 ± 0.5	−2.1 ± 0.2	−2 ± 0.5	<0.01

Table VI.  Beck depression scale scores.

	Group 1	Group 2	Group 3	p value
Baseline	12.6 ± 5.9	9.7 ± 5.3	12.5 ± 3.5	0.81
Sixth month	11.4 ± 5.6	8.7 ± 5.1	11.7 ± 3.4	0.81
Twelfth month	10.1 ± 5.2	7.7 ± 4.2	11.2 ± 3.5	0.51
p value	<0.001	<0.001	<0.001