Association of bioavailable estradiol levels and testosterone levels with serum albumin levels in elderly men

Figures & data

Table I.  Summarized values of sex steroid, albumin and SHBG levels in serum from 765 elderly men.

	Mean	SD
Total E2(pg/mL)	23.36	17.05
Free-E2 (pg/mL)	0.44	0.25
Alb-E2 (pg/mL)	13.63	7.75
Bioavailable-E2 (pg/mL)	14.14	7.95
Total T (ng/dL)	421.73	154.72
Free-T (pg/mL)	7.24	2.35
Alb-T (ng/dL)	159.27	54.06
Bioavailable-T (ng/dL)	160.01	56.17
FSH (mIU/mL)	15.28	12.26
LH (mIU/mL)	8.92	8.41
Alb (g/dL)	4.18	0.28
SHBG (nmol/L)	28.63	11.06

Table II.  Correlation coefficients for association of age with sex steroid levels and serum albumin and SHBG concentrations.

	r	p-value	Change in concentration
			Change/year	%Change/year
Total E2(pg/mL)	−0.0636	0.0469	−0.0182	0.0771
Free-E2 (pg/mL)	−0.4564	<0.0001	−0.0096	0.8622
Alb-E2 (pg/mL)	−0.4887	<0.0001	−0.3428	0.9067
Bioavailable-E2 (pg/mL)	−0.4879	<0.0001	−0.3525	0.9054
Total T (ng/dL)	−0.1276	0.0084	−2.2151	0.3833
Free-T (pg/mL)	−0.4837	<0.0001	−0.1310	0.7949
Alb-T (ng/dL)	−0.5193	<0.0001	−3.2640	0.8381
Bioavailable-T (ng/dL)	−0.5189	<0.0001	−3.3950	0.8363
FSH (mIU/mL)	+0.4942	<0.0001	+0.6651	2.1033
LH (mIU/mL)	+0.4578	<0.0001	+0.3434	2.2446
Alb (g/dL)	−0.3535	<0.0001	−0.0116	0.2330
SHBG (nmol/L)	+0.2908	<0.0001	+0.0126	0.6418

r: correlation coefficient.

Figure 1. The correlation coefficients between serum albumin concentrations and sex steroid levels in elderly men.

Figure 2. The correlation coefficients between serum SHBG concentrations and sex steroid levels in elderly men.

Table III.  Age related changes of the relationship between sex steroid levels and serum albumin concentration.

Age (yrs)	36–49 (n = 114)		50–59 (n = 178)		60–69 (n = 191)		70–79 (n = 153)		80–96 (n = 129)
	r	p-value	r	p-value	r	p-value	r	p-value	r	p-value
Total E2	0.1329	0.4918	−0.0295	0.8425	0.0404	0.6810	0.0279	0.7475	−0.1640	0.0841
Free-E2	0.1287	0.5058	0.0362	0.8072	0.1165	0.2345	0.0995	0.2490	−0.0450	0.6372
Alb-E2	0.2017	0.2940	0.1966	0.1805	0.2088	0.0317	0.2271	0.0078	0.1052	0.2698
Bioavailable-E2	0.1996	0.2991	0.1919	0.1913	0.2061	0.0340	0.2232	0.0090	0.1003	0.2927
Total T	−0.2476	0.1954	−0.2208	0.1315	0.1348	0.1682	0.0303	0.7263	0.0261	0.7851
Free-T	0.0713	0.7134	0.1003	0.4975	0.1198	0.2212	0.2554	0.0870	0.2324	0.0737
Alb-T	0.2254	0.2398	0.2895	0.0460	0.3577	0.0002	0.4150	0.0001	0.3812	0.0002
Bioavailable-T	0.2193	0.2531	0.2817	0.0524	0.3485	0.0003	0.4086	0.0001	0.3752	0.0003

r: correlation coefficient. Values with statistical significances are underlined.

Table IV.  Age related changes of the relationship between sex steroid levels and serum SHBG concentration.

Age (yrs)	36–49 (n = 114)		50–59 (n = 178)		60–69 (n = 191)		70–79 (n = 153)		80–96 (n = 129)
	r	p-value	r	p-value	r	p-value	r	p-value	r	p-value
Total E2	−0.2806	0.1403	−0.1098	0.4575	0.1355	0.1301	0.1167	0.1902	0.1124	0.2379
Free-E2	−0.2207	0.2499	−0.0487	0.7425	−0.1887	0.0539	−0.0687	0.4269	0.1024	0.2829
Alb-E2	−0.2279	0.2345	−0.0790	0.5936	−0.1767	0.0686	−0.0292	0.7356	0.0911	0.3396
Bioavailable-E2	−0.2277	0.2349	−0.0781	0.5977	−0.1771	0.0677	−0.0304	0.7250	0.0915	0.3373
Total T	0.1813	0.3465	0.2253	0.1236	−0.0818	0.4044	0.1022	0.2362	0.1332	0.1613
Free-T	0.0988	0.6101	−0.0135	0.9275	−0.1382	0.1286	−0.0071	0.9342	0.1373	0.1487
Alb-T	0.0712	0.7135	−0.0381	0.7971	−0.1676	0.0723	−0.0570	0.5095	0.0993	0.2977
Bioavailable-T	0.0724	0.7090	−0.0371	0.8023	−0.1669	0.0753	−0.0550	0.5247	0.1009	0.2897

r: correlation coefficient.

Table V.  The relationship between sex steroid levels and SHBG concentration at different albumin concentrations.

Albumin concentration (g/dL)	3.0–3.5 (n = 83)		3.6–4.0 (n = 144)		4.1–4.5 (n = 433)		4.6–5.0 (n = 105)
	r	p-value	r	p-value	r	p-value	r	p-value
Total E2	−0.1193	0.7269	−0.0034	0.9736	0.1291	0.0581	0.0368	0.8339
Free-E2	−0.3724	0.0593	−0.1368	0.0792	−0.0133	0.8461	0.1633	0.3486
Alb-E2	−0.3578	0.0800	−0.1384	0.0741	−0.0181	0.7915	0.1629	0.3498
Bioavailable-E2	−0.3599	0.0743	−0.1387	0.0733	−0.0172	0.8014	0.1631	0.3491
Total T	−0.0826	0.8093	−0.0426	0.6767	0.0158	0.8169	0.2537	0.1414
Free-T	−0.2301	0.0495	−0.1901	0.0408	0.0064	0.9252	0.0968	0.5801
Alb-T	−0.1944	0.0425	−0.1822	0.0385	−0.0009	0.9898	0.0812	0.6427
Bioavailable-T	−0.1956	0.0434	−0.1832	0.0390	−0.0001	0.9993	0.0883	0.6244

r: correlation coefficient. Values with statistical significances are underlined.