Anaemia following initiation of androgen deprivation therapy for metastatic prostate cancer: A retrospective chart review

Figures & data

Table I.  Number of patients receiving each form of therapy.

Therapy received	Number of patients (n = 43)
External beam radiation and orchiectomy	2
External beam radiation, leuprolide and bicalutamide	2
External beam radiation and leuprolide alone	2
Combination chemotherapy and leuprolide alone	2
Goserilin and bicalutamide	3
Leuprolide alone	11
Leuprolide and bicalutamide	21

Table II.  Average age, haemoglobin levels and GFR of patients undergoing ADT.

Average age	70.12 years
Haemoglobin beginning	14.3 g/dL
Haemoglobin after 3 to 9 months	13.0 g/dL
Average GFR at 3 to 9 months of therapy	69 ml/min/1.73 m^2

Table III.  Effect of treatment on haemoglobin levels.

Treatment	Number of patients	Mean haemoglobin (g/dL) decrease	Haemoglobin (g/dL) decrease range
Leuprolide alone	11	−1.66*	−0.9–−2.8
Leuprolide with bicalutamide	21	−0.78^†	−0.2–−3.4

*p < .0001.

^†p = 0.0426.

Table IV.  Linear regression analysis of change in haemoglobin.

Parameter estimates
Term	Estimate	Prob > |t|
Intercept	5.870113	0.0015
Symptom	−0.675482	0.0075
Age	−0.048364	0.0455
Leuprolide therapy	−0.697754	0.015
Creatinine	−0.688939	0.1244
R-squared	0.33