Association between severity of lower urinary tract symptoms, erectile dysfunction and metabolic syndrome

Figures & data

Table I.  Demographic, laboratory and questionnaire data of patients according to LUTS severity

	LUTS severity
	Moderate	Severe	p
N	135	55	–
Age (years)	59.7 ± 8.4	59.6 ± 7.4	0.907
Cystolic blood pressure (mmHg)	125.7 ± 15.4	128.9 ± 18.3	0.220
Diastolic blood pressure (mmHg)	78.9 ± 9.3	80.5 ± 8.7	0.274
Height (cm)	169.4 ± 6.5	170.4 ± 5.1	0.563
Weight (kg)	78.2 ± 12.1	80.6 ± 14.8	0.263
Waist circumference (cm)	98.9 ± 9.9	102.8 ± 13.8	0.033
Smoking duration (packet/yıl)	12.9 ± 18.1	17.6 ± 24.5	0.016
BMI (kg/m^2)	27.2 ± 3.6	27.8 ± 4.7	0.326
LUTS duration (month)	23.1 ± 31.5	28.7 ± 30	0.262
IPSS	12.2 ± 3.5	24.1 ± 3.6	–
QoL	2.9 ± 1.1	4.3 ± 0.7	<0.001
FBG (mg/dl)	106.9 ± 37.8	120.0 ± 49.7	0.050
Triglyceride (mg/dl)	130.5 ± 74.6	147.1 ± 135.9	0.284
HDL cholesterol (mg/dl)	43.8 ± 11.7	43.4 ± 12.1	0.823
Testosterone (ng/dl)	443.6 ± 179.7	438.7 ± 145.8	0.860
Sexual intercourse (per moth)	4.4 ± 4.0	3.2 ± 2.6	0.036
IIEF-EF	19.2 ± 9.3	16.2 ± 9.5	0.049
IIEF-OF	7.1 ± 3.3	5.9 ± 3.6	0.031
IIEF-SD	6.2 ± 2.2	5.5 ± 2.2	0.069
IIEF-IS	8.4 ± 4.3	6.9 ± 4.5	0.037
IIEF-OS	6.6 ± 2.7	5.6 ± 2.7	0.023
Metabolic syndrome (%)	25.9	45.5	0.009

LUTS, lower urinary tract symptoms; BMI, body mass index, IPSS, international prostate symptom score; QoL, quality of life; FBG, fasting blood glucose; HDL, high density lipoprotein; MFR, maximum flow rate; AFR, average flow rate; IIEF-EF, international index of erectile function-erectile function; IIEF-OF, international index of erectile function-orgasmic function; IIEF-SD, international index of erectile function-sexual desire; IIEF-IS, international index of erectile function-intercourse satisfaction; IIEF-OS, international index of erectile function-overall satisfaction.

Table II.  Frequency of patients according to the severity of LUTS and the presence of the metabolic risk factor

	Moderate LUTS	Severe LUTS	OR	p*
HT (≥130/85 mmHg)	78 (57.8%)	41 (74.5%)	2.1 (1.07–4.29)	0.030
FBG (≥110 mg/dl)	33 (24.4%)	25 (45.5%)	2.6 (1.33–4.98)	0.004
TG (>150 mg/dl)	37 (27.4%)	15 (27.3%)	0.99 (0.49–2.01)	0.985
HDL (<40 mg/dl)	47 (34.8%)	22 (40%)	1.24 (0.67–2.38)	0.500
WC (>102 cm)	52 (38.5%)	30 (54.5%)	1.9 (1.02–3.61)	0.043
Presence of MS	35 (25.9%)	25 (45.5%)	2.4 (1.24–4.59)	0.009
Presence of ED	88 (65.2 %)	45 (81.8 %)	2.4 (1.11–5.20)	0.023

*Probability values were calculated using χ² tests.

LUTS, lower urinary tract symptoms; OR, odds ratio; HT, hypertension; FBG, fasting blood glucose; TG, triglyceride; HDL, high density lipoprotein; WC, waist circumference.

Table III.  Multiple logistic regression analysis risk factors for LUTS severity

Risk factors	Beta Coefficient	S.E.	OR	95% CI	P
Age	−0.02	0.02	0.98	0.94–1.02	0.394
Smoking (packet/year)	0.01	0.01	1.01	0.99–1.03	0.148
Abnormal WC	0.27	0.42	1.31	0.58–2.99	0.516
Abnormal TA	0.52	0.42	1.67	0.74–3.80	0.218
Abnormal FPG	0.74	0.41	2.09	0.93–4.67	0.074
Abnormal Tg	−0.35	0.45	0.71	0.29–1.71	0.706
Abnormal HDL	0.11	0.43	1.11	0.48–2.60	0.806
Presence of ED	0.84	0.42	2.31	1.01–5.27	0.048
Prescence of MS	0.24	0.63	1.28	0.37–4.37	0.698

OR, odds ratio; CI, confidence interval; WC, waist circumference; FBG, fasting blood glucose; TG, triglyceride; HDL, high density lipoprotein; ED, erectile dysfunction; TA, tension arterial; MS, metabolic syndrome.