The correlation between highly sensitive C-reactive protein levels and erectile function among men with late-onset hypogonadism

Figures & data

Table 1. The correlations between SHIM score and each parameter based on Spearman rank test.

Variables		SHIM	Age	FT	PSA	BMI	Weist	HbA1c	AMS	IPSS	hs-CRP	SBP	DBP	T-Chol	TG	HDL
SHIM	r	1.000	−0.246*	0.084	−0.105	−0.124	−0.042	0.093	−0.320*	−0.350*	−0.229*	−0.103	−0.040	0.100	0.132	0.091
	p values		0.027	0.257	0.208	0.178	0.375	0.242	0.006	0.003	0.037	0.224	0.389	0.249	0.185	0.269
Age	r		1.000	−0.316*	0.224*	−0.051	0.009	0.052	−0.155	0.157	0.287*	0.082	−0.088	0.045	−0.239*	0.187
	p values			0.003	0.025	0.334	0.470	0.332	0.098	0.099	0.006	0.248	0.239	0.367	0.033	0.076
FT	r			1.000	−0.095	−0.128	−0.104	0.166	0.000	−0.089	−0.243*	0.048	0.000	−0.072	0.156	−0.192
	p values				0.205	0.140	0.188	0.080	0.498	0.234	0.017	0.346	0.499	0.293	0.116	0.070
PSA	r				1.000	−0.071	−0.034	−0.053	−0.078	0.043	0.069	−0.032	−0.008	0.013	−0.309*	0.108
	p values					0.276	0.384	0.327	0.260	0.362	0.276	0.397	0.473	0.462	0.008	0.205
BMI	r					1.000	0.260*	−0.159	0.078	−0.069	0.108	0.288*	0.315*	0.138	0.145	−0.004
	p values						0.014	0.096	0.264	0.292	0.182	0.008	0.005	0.147	0.135	0.488
Weist	r						1.000	0.093	−0.019	−0.096	0.235*	−0.030	0.122	−0.053	−0.067	−0.105
	p values							0.221	0.440	0.221	0.021	0.402	0.163	0.347	0.308	0.215
HbA1c	r							1.000	0.096	−0.053	0.008	0.214*	0.052	−0.048	−0.049	−0.179
	p values								0.218	0.337	0.473	0.041	0.342	0.361	0.356	0.090
AMS	r								1.000	0.372*	0.040	−0.121	−0.173	0.015	0.079	0.059
	p values									0.001	0.370	0.169	0.089	0.457	0.281	0.330
IPSS	r									1.000	−0.075	−0.190	−0.167	−0.071	0.019	−0.003
	p values										0.271	0.068	0.101	0.304	0.444	0.491
hs-CRP	r										1.000	−0.150	−0.084	0.003	−0.180	0.163
	p values											0.106	0.249	0.490	0.085	0.107
SBP	r											1.000	0.403*	0.116	−0.134	−0.018
	p values												0.0003	0.193	0.158	0.447
DBP	r												1.000	0.056	−0.005	0.033
	p values													0.341	0.486	0.406
T-Chol	r													1.000	0.378*	0.391*
	p values														0.001	0.001
TG	r														1.000	−0.261*
	p values															0.022
HDL	r															1.000
	p values

SHIM: Sexual Health Inventory for men; FT: free testosterone; PSA: prostate specific antigen; BMI: body mass index; HbA1c: hemoglobin A1c; AMS: Aging Male Symptoms; IPSS: International Prostate Symptom Score; hs-CRP: highly sensitive C-reactive protein; SBP: systolic blood pressure; DBP: diastolic blood pressure; T-chol: total cholesterol; TG: triglyceride; HDL-chol: high density lipoprotein cholesterol.

* Statistically significant (p < 0.05).

Table 2. The correlations between SHIM score and each parameter based on age-adjusted analysis.

		SHIM	FT	PSA	BMI	Weist	HbA1c	AMS	IPSS	hs-CRP	SBP	DBP	T-Chol	TG	HDL
SHIM	r	1.000	0.024	−0.037	−0.183	0.022	0.036	−0.181	−0.322*	−0.304*	−0.041	−0.017	0.141	0.031	0.030
	p values		0.429	0.387	0.087	0.434	0.393	0.111	0.006	0.009	0.382	0.453	0.173	0.419	0.420
FT	r		1.000	0.023	−0.123	−0.163	0.240*	0.000	−0.022	−0.154	0.145	0.025	−0.049	0.085	−0.047
	p values			0.421	0.151	0.082	0.021	0.499	0.429	0.092	0.116	0.420	0.356	0.260	0.361
PSA	r			1.000	−0.063	−0.045	−0.130	−0.002	−0.087	0.108	−0.071	−0.077	−0.049	−0.251*	−0.002
	p values				0.299	0.352	0.138	0.494	0.240	0.177	0.280	0.267	0.356	0.027	0.493
BMI	r				1.000	0.240*	−0.119	0.055	−0.076	0.145	0.208	0.332*	0.215	0.144	0.217*
	p values					0.023	0.166	0.329	0.276	0.113	0.043	0.003	0.051	0.138	0.049
Weist	r					1.000	0.149	−0.026	−0.203	0.146	−0.035	0.096	−0.026	0.216	−0.096
	p values						0.110	0.417	0.051	0.108	0.388	0.222	0.424	0.053	0.240
HbA1c	r						1.000	0.072	−0.082	−0.020	0.278*	0.076	−0.162	−0.086	−0.162
	p values							0.282	0.259	0.434	0.012	0.277	0.115	0.263	0.114
AMS	r							1.000	0.308*	0.143	−0.062	−0.148	−0.014	0.043	0.038
	p values								0.005	0.118	0.313	0.127	0.459	0.375	0.389
IPSS	r								1.000	−0.064	−0.234*	−0.184	−0.091	−0.004	−0.114
	p values									0.303	0.034	0.081	0.257	0.490	0.206
CRP	r									1.000	−0.205*	−0.098	−0.110	−0.148	0.191
	p values										0.044	0.216	0.203	0.132	0.073
SBP	r										1.000	0.431*	0.092	−0.075	−0.076
	p values											<0.001	0.247	0.289	0.288
DBP	r											1.000	0.007	−0.111	−0.036
	p values												0.481	0.212	0.398
T-Chol	r												1.000	0.276*	0.456*
	p values													0.017	<0.001
TG	r													1.000	−0.184
	p values														0.081
HDL	r														1.000
	p values

SHIM: Sexual Health Inventory for men; FT: free testosterone; PSA: prostate specific antigen; BMI: body mass index; HbA1c: hemoglobin A1c; AMS: Aging Male Symptoms; IPSS: International Prostate Symptom Score; hs-CRP: highly sensitive C-reactive protein; SBP: systolic blood pressure; DBP: diastolic blood pressure; T-chol: total cholesterol; TG: triglyceride; HDL-chol: high density lipoprotein cholesterol.

* Statistically significant (p < 0.05).

Table 3. Comparison in each patients' background between Groups A and B.

	Group A	Group B
	(n = 17)	(n = 60)	p values
hs-CRP value (mg/dl)	0.176 ± 0.059	0.049 ± 0.035
Age (years)	69.3 ± 6.8	64.2 ± 8.3	0.0273
FT value (pg/ml)	5.8 ± 2.4	7.5 ± 2.0	0.00581
PSA value (mg/dl)	0.90 ± 0.55	0.78 ± 0.41	0.176
BMI	24.9 ± 3.7	23.6 ± 3.1	0.111
Weist size (cm)	90.0 ± 14.5	87.5 ± 9.4	0.231
SBP (mmHg)	121 ± 11	131 ± 15	0.102
DBP (mmHg)	73 ± 11	76 ± 11	0.293
AMS score	43.0 ± 5.7	38.5 ± 10.7	0.0921
IPSS	10.9 ± 9.9	9.3 ± 7.0	0.271
SHIM score	7.1 ± 3.9	12.1 ± 5.7	0.0165
T-chol (mg/dl)	170 ± 50	180 ± 30	0.222
TG (mg/dl)	87 ± 35	124 ± 103	0.147
HDL-chol (mg/dl)	65 ± 32	54 ± 12	0.0914
HbA1c (%)	6.2 ± 0.7	6.4 ± 1.1	0.139

hs-CRP: highly sensitive C-reactive protein; FT: free testosterone; PSA: prostate specific antigen; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; AMS: Aging Male Symptoms; IPSS: International Prostate Symptom Score; SHIM: Sexual Health Inventory for men; T-chol: total cholesterol; TG: triglyceride; HDL-chol: high density lipoprotein cholesterol; HbA1c: hemoglobin A1c.

Table 4. A multivariate regression analysis for factors affecting CVD risk based on hs-CRP levels.

Variables	Odd's ratio	95% confidence interval	p values
Age (years)	0.953	0.810–1.121	0.56
FT value (pg/ml)	0.770	0.288–2.058	0.602
AMS score	0.954	0.850–1.072	0.432
SHIM score	0.796	0.637–0.995	0.045
HDL-chol (mg/dl)	0.999	0.984–1.015	0.91

CVD: cardiovascular disease; hs-CRP: highly sensitive C-reactive protein; FT: free testosterone; AMS: Aging Male Symptoms; SHIM: Sexual Health Inventory for men; HDL-chol: high density lipoprotein cholesterol.