The association between hypogonadism symptoms with serum testosterone, FSH and LH in men

Figures & data

Table 1. Quantitative sociodemographic variables.

Variables	Mean	SD	Median	Minimum	Maximum
Age	52.06	7.96	51.00	40	76
Body mass index (kg/m^2)	27.16	4.04	27.02	18.60	41.66
Monthly income (Dollar)	506	37.00	394	66	1970
Smoking status (Pack Year)	11.53	12.67	16.25	1.05	54.00
Systolic blood pressure (mmHg)	128.17	16.44	125	90	180
Diastolic blood pressure (mmHg)	74.39	12.18	70	40	100
Somatic symptoms (Score)	12.72	5.24	12	7	31
Psychological symptoms (Score)	11.12	4.57	10	5	25
Sexual symptoms (Score)	9.92	4.13	9.50	5	25
Total score (AMS)	33.77	11.34	32	17	76
Total testosterone (ng/dl)	412.37	143.88	413.54	48.99	841.50
Free testosterone (pg/ml)	13.23	5.71	12.20	2.30	30.50
Luteinizing hormone (IU/l)	4.90	2.71	4.15	0.32	17.80
Follicle-stimulating hormone (IU/l)	5.48	4.63	4.35	1.20	33.30

Kilogram/square meter: kg/m²;

Millimeter of mercury: mmHg;

Ageing Males' Symptoms: AMS;

Nanograms per deciliter (ng/dL);

Picogram/milliliter: pg/ml;

Units Per Liter (IU/L).

Table 2. Comparison the mean of LOH symptoms score according to anthropometric, socioeconomic and biochemical parameters.

			Somatic symptoms score		Psychologicalsymptoms score		Sexual symptoms score		Total score
Variables	Status	N	(M ± SD)	p	(M ± SD)	p	(M ± SD)	p	(M ± SD)	p
Age	40–49 years	67	13.01 ± 5.99	.387	10.90 ± 4.78	.604	9.21 ± 4.06	.056	33.12 ± 12.76	.437
	50–59 years	51	13.02 ± 4.82		11.59 ± 4.54		10.75 ± 3.91		35.35 ± 10.81
	Up to 60 years	22	11.14 ± 3.36		10.77 ± 4.12		10.23 ± 4.67		32.14 ± 7.18
BMI (kg/m^2)	Under weight	0	–	.132	–	.219	–	.162	–	.021
	Normal weight	36	11.28 ± 3.47		10.03 ± 4.12		9.00 ± 3.22		30.31 ± 7.22
	Over weight	68	12.53 ± 5.03		11.31 ± 4.37		9.72 ± 4.06		33.56 ± 10.40
	Obesity	36	14.53 ± 6.59		11.89 ± 5.27		11.25 ± 4.84		37.67 ± 14.96
Educational level	Illiterate	13	15.54 ± 7.08	.485	12.15 ± 5.13	.565	10.23 ± 5.12	.52	37.92 ± 14.12	.389
	Prehigh school	58	12.71 ± 5.64		11.29 ± 4.18		10.52 ± 4.17		34.52 ± 11.54
	Diploma	41	12 ± 3.50		10.98 ± 4.54		9.32 ± 3.55		32.29 ± 8.43
	College level	28	12.50 ± 5.45		10.54 ± 5.27		9.46 ± 4.43		32.50 ± 13.15
Occupation	Self-employed	70	14.06 ± 6.04	.028	12.29 ± 4.88	.018	10.46 ± 4.33	.158	36.80 ± 12.91	.005
	Employee	42	11.48 ± 4.07		10.05 ± 4.19		9.81 ± 3.97		31.33 ± 8.79
	Worker	28	11.25 ± 3.79		9.86 ± 3.65		8.79 ± 3.78		29.89 ± 8.42
Monthly income status	<350 dollars	66	12.82 ± 5.54	.751	11.53 ± 4.66	.528	10.20 ± 4.30	.650	34.55 ± 12.33	.751
	350–700 dollars	48	12.17 ± 4.50		10.92 ± 4.58		9.92 ± 4.09		33.00 ± 10.60
	>700 dollars	26	13.50 ± 5.83		10.50 ± 4.43		9.27 ± 3.89		33.27 ± 10.31
Smoking status	Yes	35	13.97 ± 6.57	.276	12.54±±5.14	.530	9.51 ± 4.38	.315	36.03 ± 13.28	.176
	No	105	12.30 ± 4.69		10.66 ± 4.30		10.07 ± 4.07		33.03 ± 10.58
SBP (mmHg)	Normal	31	11.87 ± 4.43	.766	10.61 ± 4.04	.962	9.06 ± 3.89	.477	31.55 ± 10.40	.368
	Prehypertension	68	13.12 ± 6.03		11.43 ± 4.94		10.37 ± 4.15		34.91 ± 12.43
	Stage 1 HTN	28	11.71 ± 3.28		11.04 ± 4.85		9.46 ± 3.75		32.21 ± 9.17
	Stage 2 HTN	13	14.85 ± 5.76		11 ± 3.44		10.69 ± 5.34		36.54 ± 11.60
DBP (mmHg)	Normal	77	12.62 ± 5.52	.521	11 ± 4.79	.925	9.79 ± 4.03	.680	33.42 ± 12.03	.429
	Prehypertension	32	12.19 ± 4.99		11.16 ± 4.36		9.22 ± 3.88		32.56 ± 10.05
	Stage 1 HTN	25	13.76 ± 5.04		11.56 ± 4.66		11.72 ± 4.45		37.04 ± 11.37
	Stage 2 HTN	6	12.50 ± 4.32		10.83 ± 3.19		8.00 ± 4.15		31.33 ± 7.76
TT (ng/dl)	Low	8	17.37 ± 8.95	.03	13 ± 5.15	.45	9.37 ± 4.80	.40	39.75 ± 17.11	.29
	Low-borderline	37	12.35 ± 4.58		11.29 ± 3.85		9.21 ± 4.02		32.86 ± 9.30
	High	95	12.47 ± 4.97		10.90 ± 4.79		10.25 ± 4.13		33.63 ± 11.48
FT (pg/ml)	Low	5	16.20 ± 9.36	.13	10.40 ± 4.92	.71	8.80 ± 2.86	.53	35.40 ± 14.60	.74
	Normal	135	12.59 ± 5.04		11.15 ± 4.58		9.97 ± 4.18		33.71 ± 11.26

Significantly p values <.05.

Systolic blood pressure: SBP.

Diastolic blood pressure: DBP.

Total testosterone: TT.

Free testosterone: FT.

Table 3. Spearman's correlation coefficients between quantitative variables.

Variables	(1)	(2)	(3)	(4)	(5)	(6)	(7)	(8)	(9)	(10)	(11)	(12)	(13)	(14)
(1) Age	1.0
(2) BMI (kg/m^2)	−.17*	1.00
(3) income	.05	.01	1.0
(4) Smoking status (pack-year)	.03	.24	−.10	1.0
(5) Systolic blood pressure (mmHg)	.35**	.07	−.03	.39*	1.0
(6) Diastolic blood pressure (mmHg)	.29**	.09	−.08	.37*	.88**	1.0
(7) Psychological symptoms	.06	.16	−.09	.19	.01	.04	1.0
(8) Sexual symptoms	.24**	.11	−.09	.06	.05	.05	.32**	1.0
(9) Somatic symptoms	−.00	.17*	.03	.23	.10	.09	.54**	.36**	1.0
(10) Total score (AMS)	.15	.16*	−.02	.18	.10	.10	.80**	.68**	.80**	1.0
(11) total testosterone (ng/dl)	−.10	−.11	−.14	−.24	−.09	−.09	−.11	.04	−.03	−.05	1.0
(12) Free testosterone (pg/ml)	−.13	.03	−.03	−.10	−.04	−.01	−.06	−.06	−.04	−.08	.38**	1.0
(13) LH (IU/L)	.25**	.01	−.03	.07	.04	−.00	.12	.06	.08	.11	.06	.26**	1.0
(14) FSH (IU/L)	.34**	−.01	−.09	.28	.05	.06	.10	.08	.10	.12	−.01	.10	.60**	1.0

* Correlation is significant at the 0.05 level (2-tailed).

** Correlation is significant at the 0.01 level (2-tailed).

Figure 1. Effect of age (years) on LH &FSH levels.

Table 4. Logistic regression analyses of LOH symptoms related to anthropometric, socioeconomic and biochemical parameters.

					95% CI. For ORs
Variables	B	S.E.	p Value	Odds ratio	Lower	Upper
Age	.046	.025	.064	1.05	.997	1.099
Occupation^a	1.477	.578	.011	4.380	1.411	13.597
Occupation^b	1.143	.613	.062	3.137	.944	10.428
Smoking status	.789	.430	.067	2.201	.947	5.116
BMI	.138	.052	.008	1.148	1.037	1.271
Constant	−7.965	2.263	.000	0.000

^a Self-employed VS worker.

^b Employee VS worker.