Is there a relationship between hematological parameters and duration of respiratory events in severe OSA

Figures & data

Table 1. The demographic characteristics of the study population.

Characteristics (n = 120)	Values
Male (number)	81
Female (number)	39
Height, cm	169.50 ± 8.63
Weight, kg	93.50 (min–max: 69–145)
BMI^a, kg/m^2	32.4 (min–max: 22–54)
AHI	61.10 ± 18.32
MOAD^b	23.89 ± 6.94
MMAD^b	28 (min–max: 14–59)
MSAD^b	24 (min–max: 11–39)
MTAD^b	24.04 ± 6.90
MHD^b	26 (min–max: 14–58)

^a BMI: body mass index.

^bMOAD: mean obstructive apnea duration; MMAD: mean mixed apnea duration; MCAD: mean central apnea duration; MTAD: mean total apnea duration; MHD: mean hypopnea duration.

Table 2. The relationship of hematological parameters and MOAD, MMAD, MSAD, MTAD, MHD.

	Hgb	RDW	PDW	NLR	PLR	MPV
MOAD	r = 0.351	r = −0.321	r = −0.135	r = 0.074	r = 0.009	r = 0.020
	p = <.001	p = <.001	p = .143	p = .425	p = .920	p = .829
MMAD	r = 0.384	r = −0.173	r = −0.083	r = −0.042	r = −0.072	r = −0.025
	p = <.001	p = .058	p = .366	p = .645	p = .437	p = .790
MSAD	r = 0.246	r = −0.133	r = −0.048	r = 0.023	r = 0.026	r = −0.055
	p = .007	p = .147	p = .602	p = .808	p = .782	p = .547
MTAD	r = 0.367	r = −0.312	r = −0.127	r = 0.080	r = −0.014	r = 0.015
	p = <.001	p = .001	p = .169	p = .386	p = .878	p = .867
MHD	r = 0.188	r = −0.315	r = 0.275	r = 0.007	r = 0.040	r = 0.112
	p = .040	p = <.001	p = .002	p = .943	p = .665	p = .224

MOAD: mean obstructive apnea duration; MMAD: mean mixed apnea duration; MCAD: mean central apnea duration; MTAD: mean total apnea duration; MHD: mean hypopnea duration.

Bold: p < .05, statistically significant.

Table 3. The relationship of hematological parameters and polysomnographic sleep parameters.

	Hgb	RDW	PDW	NLR	PLR	MPV
Number of awakenings	r = −0.065	r = 0.055	r = 0.096	r = −0.058	r = 0.047	r = −0.196
	p = .479	p = .550	p = .299	p = .526	p = .607	p = .032
Sleep latency	r = −0.076	r = 0.271	r = 0.034	r = 0.045	r = −0.055	r = −0.047
	p = .412	p = .003	p = .711	p = .625	p = .553	p = .607
Total sleep time	r = 0.197	r = −0.139	r = −0.013	r = −0.041	r = 0.014	r = −0.067
	p = .031	p = .129	p = .889	p = .656	p = .882	p = .464
Sleep efficiency	r = 0.219	r = −0.244	r = 0.012	r = 0.024	r = 0.006	r = 0.017
	p = .016	p = .007	p = .896	p = .793	p = .950	p = .853
REM latency	r = 0.020	r = −0.158	r = −0.134	r = −0.084	r = 0.051	r = −0.020
	p = .826	p = .084	p = .145	p = .360	p = .557	p = .829
WASO^a	r = −0.191	r = 0.226	r = −0.035	r = −0.064	r = 0.018	r = −0.052
	p = .037	p = .013	p = .707	p = .486	p = .849	p = .576
Duration of REM (min)	r = 0.180	r = −0.197	r = −0.108	r = −0.220	r = −0.182	r = 0.018
	p = .049	p = .031	p = .241	p = .016	p = .047	p = .848
Duration of N1 Sleep (min)	r = −0.414	r = 0.263	r = 0.133	r = 0.148	r = 0.166	r = −0.094
	p = .125	p = .004	p = .148	p = .108	p = .069	p = .307
Duration of N2 Sleep (min)	r = 0.258	r = −0.152	r = 0.072	r = 0.116	r = 0.070	r = −0.052
	p = .004	p = .097	p = .436	p = .208	p = .447	p = .571
Duration of N3 Sleep (min)	r = −0.112	r = −0.139	r = −0.156	r = −0.253	r = −0.128	r = 0.010
	p = .225	p = .131	p = .088	p = .005	p = .162	p = .911
REM Sleep (%)	r = 0.112	r = −0.159	r = −0.111	r = −0.236	r = −0.183	r = 0.050
	p = .224	p = .083	p = .228	p = .010	p = .045	p = .590
N1 Sleep (%)	r = −0.179	r = 0.303	r = 0.147	r = 0.153	r = 0.151	r = −0.054
	p = .050	p = .001	p = .109	p = .095	p = .100	p = .557
N2 Sleep (%)	r = 0.191	r = −0.050	r = 0.081	r = 0.167	r = 0.112	r = −0.061
	p = .036	p = .586	p = .381	p = .069	p = .224	p = .506
N3 Sleep (%)	r = −0.149	r = −0.117	r = −0.172	r = −0.238	r = −0.136	r = 0.026
	p = .105	p = .203	p = .060	p = .009	p = .138	p = .780
AHI-REM	r = −0.081	r = 0.048	r = −0.024	r = −0.035	r = −0.122	r = −0.113
	p = .378	p = .600	p = .798	p = .701	p = .184	p = .217
AHI-NREM	r = 0.062	r = 0.139	r = 0.159	r = −0.003	r = −0.021	r = −0.116
	p = .499	p = .131	p = .082	p = .971	p = .821	p = .208
AHI	r = 0.039	r = 0.155	r = 0.154	r = −0.005	r = −0.038	r = −0.129
	p = .672	p = .090	p = .094	p = .958	p = .682	p = .160

^a WASO: Wakening after sleep onset.

Bold: p < .05, statistically significant.

Table 4. The relationship of hematological parameters and blood oxygen parameters.

	Hgb	RDW	PDW	NLR	PLR	MPV
Mean oxygen desaturation	r = 0.225	r = −0.085	r = −0.177	r = 0.019	r = −0.041	r = −0.016
	p = .013	p = .357	p = .053	p = .834	p = .657	p = .866
Number of desaturation (≥2)	r = 0.098	r = 0.050	r = 0.098	r = −0.023	r = 0.023	r = −0.034
	p = .285	p = .589	p = .286	p = .804	p = .801	p = .712
Desaturation index (≥2)	r = 0.026	r = 0.148	r = 0.029	r = 0.046	r = −0.017	r = 0.021
	p = .777	p = .106	p = .757	p = .614	p = .851	p = .816
Number of desaturation (≥3)	r = 0.100	r = 0.034	r = 0.090	r = −0.023	r = 0.035	r = −0.037
	p = .279	p = .714	p = .331	p = .807	p = .702	p = .688
Desaturation index (≥3)	r = 0.012	r = 0.161	r = 0.035	r = 0.047	r = −0.006	r = 0.011
	p = .897	p = .079	p = .705	p = .610	p = .946	p = .902
Number of desaturation (≥4)	r = 0.154	r = 0.005	r = 0.047	r = −0.013	r = 0.023	r = −0.033
	p = .092	p = .958	p = .607	p = .885	p = .802	p = .718
Desaturation index (≥4)	r = 0.079	r = 0.109	r = −0.009	r = 0.041	r = −0.021	r = 0.011
	p = .389	p = .236	p = .921	p = .658	p = .822	p = .902
Number of desaturation (≥5)	r = 0.194	r = −0.021	r = 0.017	r = 0.003	r = 0.020	r = −0.047
	p = .034	p = .821	p = .857	p = .970	p = .827	p = .610
Desaturation index (≥5)	r = 0.138	r = 0.082	r = −0.045	r = 0.061	r = 0.−022	r = 0.005
	p = .133	p = .376	p = .627	p = .506	p = .809	p = .960
Duration below SO2 95%	r = 0.071	r = 0.029	r = 0.008	r = 0.009	r = 0.041	r = 0.055
	p = .442	p = .753	p = .927	p = .922	p = .659	p = .549
Duration below SO2 90%	r = 0.107	r = 0.088	r = −0.053	r = 0.090	r = 0.035	r = 0.010
	p = .246	p = .342	p = .565	p = .326	p = .702	p = .912
Duration below SO2 85%	r = 0.125	r = 0.033	r = −0.115	r = 0.086	r = 0.015	r = −0.023
	p = .174	p = .720	p = .210	p = .350	p = .868	p = .805

Bold: p < .05, statistically significant.

Table 5. The relationship of hematological parameters with blood oxygen parameters and polysomnographic sleep parameters in the patients ≤50 years old.

	Hgb	RDW	PDW	NLR	PLR	MPV
MOAD	r = 0.344	r = −0.201	r = −0.086	r = 0.318	r = 0.137	r = 0.060
	p = .011	p = .145	p = .583	p = .019	p = .322	p = .666
MMAD	r = 0.212	r = −0.085	r = −0.020	r = 0.278	r = 0.226	r = 0.013
	p = .245	p = .643	p = .913	p = .123	p = .214	p = .946
MSAD	r = 0.288	r = 0.018	r = 0.102	r = 0.062	r = 0.128	r = −0.016
	p = .067	p = .911	p = .527	p = .701	p = .424	p = .922
MTAD	r = 0.376	r = −0.200	r = −0.073	r = 0.331	r = 0.123	r = 0.032
	p = .005	p = .146	p = .600	p = .015	p = .376	p = .821
MHD	r = 0.034	r = −0.326	r = −0.197	r = 0.011	r = 0.201	r = 0.078
	p = .811	p = .017	p = .156	p = .938	p = .148	p = .581
Mean oxygen desaturation	r = 0.174	r = 0.076	r = −0.051	r = 0.199	r = −0.029	r = 0.128
	p = .207	p = .585	p = .712	p = .150	p = .838	p = .358
Number of desaturation (≥2)	r = 0.093	r = 0.198	r = 0.356	r = 0.121	r = 0.000	r = 0.036
	p = .503	p = .151	p = .008	p = .383	p = 1.000	p = .793
Desaturation index (≥2)	r = −0.014	r = 0.302	r = 0.185	r = 0.193	r = −0.109	r = 0.151
	p = .920	p = .026	p = .180	p = .162	p = .433	p = .275
Number of desaturation (≥3)	r = 0.087	r = 0.185	r = 0.352	r = 0.122	r = 0.021	r = 0.026
	p = .531	p = .179	p = .009	p = .380	p = .880	p = .854
Desaturation index (≥3)	r = −0.051	r = 0.331	r = 0.203	r = 0.193	r = −0.074	r = 0.145
	p = .713	p = .015	p = .140	p = .161	p = .593	p = .295
Number of desaturation (≥4)	r = 0.151	r = 0.147	r = 0.318	r = 0.133	r = 0.035	r = 0.042
	p = .275	p = .290	p = .019	p = .338	p = .803	p = .760
Desaturation index (≥4)	r = 0.018	r = 0.261	r = 0.155	r = 0.229	r = −0.030	r = 0.154
	p = .897	p = .057	p = .262	p = .096	p = .832	p = .267
Number of desaturation (≥5)	r = 0.211	r = 0.120	r = 0.277	r = 0.158	r = 0.059	r = 0.051
	p = .125	p = .386	p = .043	p = .255	p = .674	p = .712
Desaturation index (≥5)	r = 0.091	r = 0.240	r = 0.112	r = 0.242	r = −0.031	r = 0.155
	p = .514	p = .080	p = .419	p = .078	p = .824	p = .262
Duration below SO2 95%	r = 0.076	r = 0.003	r = 0.179	r = −0.051	r = −0.020	r = 0.176
	p = .585	p = .981	p = .194	p = .715	p = .888	p = .203
Duration below SO2 90%	r = 0.211	r = 0.097	r = 0.202	r = 0.122	r = 0.058	r = 0.008
	p = .125	p = .484	p = .142	p = .379	p = .677	p = .956
Duration below SO2 85%	r = 0.203	r = 0.144	r = 0.067	r = 0.190	r = −0.016	r = −0.013
	p = .140	p = .300	p = .629	p = .170	p = .909	p = .924
AHI-REM	r = 0.004	r = 0.175	r = 0.124	r = 0.169	r = −0.193	r = −0.129
	p = .976	p = .206	p = .370	p = .221	p = .161	p = .354
AHI-NREM	r = −0.048	r = 0.278	r = 0.455	r = 0.090	r = −0.047	r = −0.147
	p = .729	p = .042	p = .001	p = .519	p = .733	p = .288
AHI	r = −0.067	r = 0.278	r = 0.415	r = 0.122	r = −0.058	r = −0.153
	p = .629	p = .042	p = .002	p = .381	p = .679	p = .271

MOAD: mean obstructive apnea duration; MMAD: mean mixed apnea duration; MCAD: mean central apnea duration; MTAD: mean total apnea duration; MHD: mean hypopnea duration.

Bold: p < .05, statistically significant.