Overweight and obesity in men with prostate cancer do not constitute risk factors for biochemical recurrence

Figures & data

Table 1. Clinicopathologic characteristics of Mexican men with prostate cancer and different body mass indexes.

Variable	Men with normal BMI n (%)	Men with overweight/obesity n (%)	p
Patients	57 (31.7)	123 (68.3)
Age at the time of diagnosis, (years)*	65 (52–77)	63 (45–79)	0.205
D’Amico classification
Low risk	19 (33.3)	39 (31.7)	0.828
Intermediate/high risk	38 (66.7)	84 (68.3)
Postsurgical PSA (ng/ml)
<0.4	48 (84.2)	109 (88.6)	0.410
≥0.4	9 (15.8)	14 (11.4)
Extraprostatic invasion	11 (19.3)	36 (29.3)	0.157
Lymph node metastases	1 (1.7)	5 (4.1)	0.422
Positive surgical margins	21 (36.8)	42 (34.1)	0.724

BMI: body mass index; n: number of men; *Age values are presented as median and range.

PSA: prostate-specific antigen.

Table 2. Cox proportional hazards analysis for biochemical recurrence free survival after radical prostatectomy in Mexican men with prostate cancer.

Variable	BRFS – univariate			BRFS – multivariate
	HR	IC	p	HR	IC	p
Age (continuous)	1.02	0.98–1.07	0.282	1.03	0.98–1.07	0.198
BMI (normal vs overweight/obesity)	0.90	0.49–1.64	0.729	0.82	0.46–1.57	0.610
D’Amico classification (low vs intermediate/high)	4.68	1.85–11.82	0.001	4.39	1.71–11.24	0.002
Extraprostatic invasion (absent vs present)	1.73	0.96–3.14	0.067	1.31	0.67–2.54	0.428
Lymph node metastases (absent vs present)	2.30	0.71–7.44	0.162	1.38	0.39–4.92	0.620
Positive surgical margins (absent vs present)	1.31	0.74–2.32	0.360	1.11	0.61–2.02	0.740

BRFS: biochemical recurrence free survival; HR: hazard ratio; 95% CI: confidence interval.

BMI: body mass index.

Figure 1. Kaplan-Meier survival estimates for biochemical recurrence free survival by body mass index (BMI). No association was found between overweight/obesity and biochemical recurrence free survival decreases.