Low free testosterone level as a predictor of cardiovascular events in Japanese men with coronary risk factors

Figures & data

Figure 1. Correlation between free testosterone and age.

Table 1. Patients' baseline characteristics by tertile group of plasma free testosterone.

n = 466	Tertile 1 (n = 157)	Tertile 2 (n = 154)	Tertile 3 (n = 155)		p
	<6.5 pg/mL	6.5–9.3 pg/mL	>9.3 pg/mL
Free testosterone (pg/mL)	5.30 (1.90)	8.10 (1.30)	11.5 (2.85)	<.01
Age (years)	72 (12)	65 (12)	60 (15)	<.01
Body mass index (kg/m^2)	22.9 (4.22)	23.4 (4.07)	23.7 (3.95)	.5
Hemoglobin A1c (%)	6.3 (1.5)	6.2 (1.4)	5.8 (1.4)	.022
Duration of diabetes (months)	30.5 (113)	41.5 (139)	44.5 (120)	.37
Hypertension, n (%)	83 (52.8)	81 (52.5)	79 (50.9)	.93
Diabetes, n (%)	94 (59.8)	100 (64.9)	111 (71.6)	.09
Dyslipidemia, n (%)	61 (38.8)	47 (30.5)	38 (24.5)	.023
Current smoker	77 (49.0)	64 (41.5)	76 (49.0)	.31

Values are expressed as median (interquartile). Continuous variables were compared by the Kruskal–Wallis H-test and categorical variables by Chi-squared test.

Figure 2. Cumulative survival of cardiovascular events by tertile group of plasma concentration of free testosterone.

Table 2. Cardiovascular events by tertile of plasma free testosterone.

n = 466	Tertile 1 (n = 157)	Tertile 2 (n = 154)	Tertile 3 (n = 155)	Total
	<6.5 pg/mL	6.5–9.3 pg/mL	>9.3 pg/mL
Stroke	8	4	12	24
Coronary artery disease	25	17	14	56
Transient ischemic attack	16	19	6	41
Retinal artery occlusion	2	1	0	3
Aneurysm of abdominal aorta	1	0	1	2
Total cardiovascular events	52	41	33	126

Table 3. Multivariate analyses of factors associated with cardiovascular events.

	HRs	95% CI	p Value
FT tertile 1 (<6.6 pg/mL)	1(Ref)
FT tertile 2 (6.6–9.2 pg/mL)	0.617	0.389–0.976	.03
FT tertile 3 (9.3 pg/mL<)	0.524	0.309–0.887	.016
Age	1.034	1.010–1.059	.005
BMI	1.042	0.977–1.111	.209
Hypertension, yes	1.848	1.199–2.849	.005
Hemoglobin A1c (%)	1.087	0.929–1.273	.297
Duration of diabetes (months)	1.002	1.001–1.004	.001
Dyslipidemia, yes	1.452	0.969–2.175	.049
Current smoker, yes	2.806	1.856–4.243	<.001

HRs: hazard ratios; CI: confidence interval; FT: free testosterone; BMI: body mass index.