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Cardiovascular

Clinical outcomes and economic impact of transcatheter mitral leaflet repair in heart failure patients

, , , , , , , & show all
Pages 82-90 | Received 27 Jun 2016, Accepted 15 Aug 2016, Published online: 21 Sep 2016

Figures & data

Figure 1. Structure of the decision model.

Figure 1. Structure of the decision model.

Table 1. Baseline characteristics of MitraClip and medical management cohorts.

Figure 2. (A) Kaplan-Meier survival curves for MitraClip and medical management cohorts. (B) Kaplan-Meier survival curves with Weibull extrapolations for MitraClip and medical therapy cohorts.

Figure 2. (A) Kaplan-Meier survival curves for MitraClip and medical management cohorts. (B) Kaplan-Meier survival curves with Weibull extrapolations for MitraClip and medical therapy cohorts.

Table 2. Comparison of outcomes in MitraClip and medical therapy cohorts at 30 days and 1 year.

Table 3. Economic outcomes for MitraClip and medical therapy.

Figure 3. Tornado diagram.

Figure 3. Tornado diagram.

Figure 4. (A) Incremental cost-effectiveness of MitraClip compared with medical therapy. Scatterplot of incremental cost (in Canadian dollars; $CDN) vs incremental quality-adjusted life year (QALY) for the 10,000 simulations comparing MitraClip with medical therapy (a willingness-to-pay threshold of $100,000 CAD is indicated). (B) Cost-effectiveness acceptability curve created from a probabilistic sensitivity analysis performed with 10,000 Monte Carlo simulations.

Figure 4. (A) Incremental cost-effectiveness of MitraClip compared with medical therapy. Scatterplot of incremental cost (in Canadian dollars; $CDN) vs incremental quality-adjusted life year (QALY) for the 10,000 simulations comparing MitraClip with medical therapy (a willingness-to-pay threshold of $100,000 CAD is indicated). (B) Cost-effectiveness acceptability curve created from a probabilistic sensitivity analysis performed with 10,000 Monte Carlo simulations.

Table 4. Comparison of outcomes in MitraClip cohort with published registry data.

Supplemental material

Appendix_A_and_B.docx

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