Healthcare resource utilization in patients receiving idarucizumab for reversal of dabigatran anticoagulation due to major bleeding, urgent surgery, or procedural interventions: interim results from the RE-VERSE AD™ study

Figures & data

Figure 1. Median time to surgery in Group B (patients undergoing emergency surgery/procedures).

Table 1. Blood product and pro-hemostatic agent use in Group A (patients with uncontrolled bleeding).

	GI (n = 20)	Subdural hemorrhage (n = 6)	Deep intracerebral and subarachnoid hemorrhage (n = 12)	Other bleeds (n = 13)	Total (n = 51)
Patients with transfusion of PRBC, n (%)	18 (90)	3 (50)	0	8 (62)	29 (57)
Median number of PRBC units per patient (min, max)	3.5 (1, 12)	2.0 (1, 4)		4.0 (2, 20)	3.0 (1, 20)
Patients with transfusions of FFP, n (%)	7 (35)	2 (33)	0	5 (38)	14 (27)
Median number of FFP units per patient (min, max)	2.0 (1, 8)	1.5 (1, 2)		2.0 (1, 10)	2.0 (1, 10)
Patients with transfusions of whole blood, n (%)	1 (5)	0	0	2 (15)	3 (6)
Median number of whole blood units per patient (min, max)	2.0			2.5 (1, 4)	2.0 (1, 4)
Patients with transfusions of cryoprecipitate, n (%)	0	0	0	2 (15)	2 (4)
Median number of cryoprecipitate units per patient (min, max)				3.5 (3, 4)	3.5 (3, 4)
Patients with transfusions of platelets, n (%)	2 (10)	1 (17)	0	3 (23)	6 (12)
Median number of platelet units per patient (min, max)	1.5 (1, 2)	4.0		2.0 (1, 4)	2.0 (1, 4)
Patients treated at least once with aPCC	1 (6)	0	0	1 (8)	2 (4)

3-PCC, 4-PCC, FVIIa not used in any patient.

3-PCC: three-factor prothrombin complex concentrates; 4-PCC: four-factor prothrombin complex concentrates; aPCC: activated prothrombin complex concentrates; FFP: fresh frozen plasma; GI: gastrointestinal; max: maximum; min: minimum; PRBC: packed red blood cells.

Table 2. Blood product and pro-hemostatic agent use in Group B (patients undergoing emergency surgery/procedures).

	Musculo-skeletal trauma surgery/procedures (n = 8)	Cardiac and vascular surgery/procedures (n = 3)	Major therapeutic abdominal surgery/ procedures (n = 10)	Exploratory abdominal surgery/procedures (n = 4)	Infections of skin and subcutaneous tissues, joint infection (n = 6)	Other surgery/procedures (n = 8)	Total (n = 39)
First transfusion on day/day after surgery
Patients with transfusion of PRBC, n (%)	2 (25)	1 (33)	0	0	1 (17)	1 (13)	5 (13)
Median number of PRBC units per patient (min, max)	6.0 (3, 9)	4.0			3.0	1.0	3.0 (1, 9)
Patients with transfusions of FFP, n (%)	1 (13)	1 (33)	3 (30)	1 (25)	0	1 (13)	7 (18)
Median number of FFP units per patient (min, max)	2.0	3.0	4.0 (1, 4)	2.0		2.0	2.0 (1, 4)
Patients with transfusions of platelets, n (%)	1 (13)	1 (33)	0	0	0	0	2 (5)
Median number of platelet units per patient (min, max)	1.0	6.0					3.5 (1, 6)
Patients treated at least once with aPCC	0	0	0	1 (25)	0	1 (13)	2 (5)
During entire study period
Patients with transfusion of PRBC, n (%)	3 (38)	1 (33)	1 (10)	0	2 (33)	2 (25)	9 (23)
Median number of PRBC units per patient (min, max)	3.0 (2, 9)	12.0	1.0		10.5 (5, 16)	2.5 (1, 4)	4.0 (1, 16)
Patients with transfusions of FFP, n (%)	1 (13)	1 (33)	3 (30)	1 (25)	2 (33)	1 (13)	9 (23)
Median number of FFP units per patient (min, max)	2.0	3.0	4.0 (1, 4)	2.0	3.5 (3, 4)	2.0	3.0 (1, 4)
Patients with transfusions of platelets, n (%)	1 (13)	1 (33)	0	0	0	0	2 (5)
Median number of platelet units per patient (min, max)	1.0	6.0					3.5 (1, 6)
Patients treated at least once with aPCC	0	0	0	1 (25)	0	1 (13)	2 (5)

3-PCC, 4-PCC, FVIIa, whole blood and cryoprecipitate not used in any patient.

3-PCC: three-factor prothrombin complex concentrates; 4-PCC: four-factor prothrombin complex concentrates; aPCC: activated prothrombin complex concentrates; FFP: fresh frozen plasma; PRBC: packed red blood cells.

Table 3. Hospital admissions for patients in Group A (patients with uncontrolled bleeding).

	GI (n = 20)	Subdural hemorrhage (n = 6)	Deep intracerebral and subarachnoid hemorrhage (n = 12)	Other bleeds (n = 13)	Total (n = 51)
Number of admitted patients with LOS of 1 or more nights, n (%)	18 (90)	5 (83)	9 (75)	10 (77)	42 (82)
Median LOS in hospital among patients admitted to hospital, bed-days (min, max)	6.0 (1, 24)	7.0 (6, 71)	9.0 (4, 47)	6.5 (1, 18)	7.0 (1, 71)
Number of patients with at least 1-day stay in ICU, n (%)	6 (30)	2 (33)	4 (33)	5 (38)	17 (33)
Median LOS in the ICU among patients with at least 1-day stay, days (min, max)	3.0 (1, 11)	24.0 (4, 44)	3.0 (1, 5)	4.0 (1, 8)	4.0 (1, 44)
Patients with re-admission to hospital within 30 days after discharge, n (%)	0	0	0	1 (8)	1 (2)

GI: gastrointestinal; ICU: intensive care unit; LOS: length of stay; max: maximum; min: minimum.

Table 4. Hospital admissions for patients in Group B (patients undergoing emergency surgery/procedures).

	Musculo-skeletal trauma surgery/procedures (n = 8)	Cardiac and vascular surgery/procedures (n = 3)	Major therapeutic abdominal surgery/procedures (n = 10)	Exploratory abdominal surgery/procedures (n = 4)	Infections of skin and subcutaneous tissues, joint infection (n = 6)	Other surgery/procedures (n = 8)	Total (n = 39)
Number of admitted patients with LOS of 1 or more nights, n (%)	8 (100)	2 (67)	10 (100)	3 (75)	6 (100)	7 (88)	36 (92)
Median LOS in hospital among patients admitted to hospital, bed-days (min, max)	24.5 (4, 92)	12.5 (7, 18)	9.0 (2, 45)	1.0 (1, 17)	20.5 (1, 61)	3.0 (1, 29)	9.0 (1, 92)
Number of patients admitted to the ICU, n (%)	2 (25)	2 (67)	4 (40)	1 (25)	3 (50)	3 (38)	15 (38)
Median LOS in the ICU, among patients with at least 1-day stay, days (min, max)	2.0 (1, 3)	3.0 (2, 4)	1.5 (1, 3)	1.0	4.0 (3, 24)	2.0 (2, 22)	2.0 (1, 24)
Patients with re-admission to hospital within 30 days after discharge, n (%)	0	0	1 (10)	0	1 (17)	0	2 (5)

ICU: intensive care unit; LOS: length of stay; max: maximum; min: minimum.