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Cardiovascular

Why published studies of the cost-effectiveness of PCSK-9 inhibitors yielded such markedly different results

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Pages 749-751 | Received 14 Apr 2017, Accepted 03 May 2017, Published online: 17 May 2017

Figures & data

Figure 1. Baseline MACE rate in ASCVD population plotted against incremental cost-effectiveness of PCSK9 inhibitor in treated but uncontrolled ASCVD patients. We have not changed any of the model inputs or their resulting ICERs except for the calculation of the ICER for Jena 2016, which was a value model not a cost-effectiveness model. The ratio of QALYs to life-years from Kazi 2016 was applied to the calculation of life-years from Jena 2016 to calculate an ICER by QALYs. MACE: major adverse cardiac events.

Figure 1. Baseline MACE rate in ASCVD population plotted against incremental cost-effectiveness of PCSK9 inhibitor in treated but uncontrolled ASCVD patients. We have not changed any of the model inputs or their resulting ICERs except for the calculation of the ICER for Jena 2016, which was a value model not a cost-effectiveness model. The ratio of QALYs to life-years from Kazi 2016 was applied to the calculation of life-years from Jena 2016 to calculate an ICER by QALYs. MACE: major adverse cardiac events.

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