The budget impact of brodalumab for the treatment of moderate-to-severe plaque psoriasis on US commercial health plans

Figures & data

Figure 1. Total annual health plan pharmacy cost difference to treat patients with moderate-to-severe plaque psoriasis with increasing proportions of patients with brodalumab usage.

Table 1. Total annual biologic drug cost for US commercial health plans.

	Brodalumab	Adalimumab	Ustekinumab	Secukinumab	Ixekizumab	Etanercept
Drug dispensing fee per Rx^10	$3	$3	$3	$3	$3	$3
Average patient co-pay per Rx^10	$51	$51	$51	$51	$51	$51
Drug cost without discount per patient-year	$47,250	$62,177	$69,155	$70,796	$81,215	$72,182
Hypothetical drug discount	20%	20%	20%	20%	20%	20%
Drug cost after discount per patient-year	$37,800	$49,742	$55,324	$56,637	$64,972	$57,746
Total patient co-pay per patient-year	$612	$612	$255	$612	$612	$612
Total annual biologic drug cost to commercial health plan pharmacy	$37,224	$49,166	$55,084	$56,061	$64,396	$57,170

Rx: Prescription.

Table 2. Total annual health plan pharmacy cost for biologic drugs used to treat patients with moderate-to-severe plaque psoriasis with increasing proportions of patients with brodalumab usage.

Proportions of patients with brodalumab usage	0%	3%	8%	16%	30%
Number of patients treated with biologic drugs
Adalimumab	3,973	3,854	3,655	3,337	2,781
Ustekinumab	1,053	1,021	969	884	737
Secukinumab	1,105	1,071	1,016	928	773
Ixekizumab	348	337	320	292	244
Etanercept	1,342	1,302	1,234	1,127	939
Brodalumab	0	235	626	1,251	2,346
Total Patients	7,820	7,820	7,820	7,820	7,820
Total health plan pharmacy payment for biologic drugs
Adalimumab	$195,324,564	$189,464,827	$179,698,599	$164,072,634	$136,727,195
Ustekinumab	$58,001,365	$56,261,324	$53,361,256	$48,721,147	$40,600,956
Secukinumab	$61,925,101	$60,067,348	$56,971,093	$52,017,085	$43,347,571
Ixekizumab	$22,402,169	$21,730,104	$20,609,995	$18,817,822	$15,681,518
Etanercept	$76,709,448	$74,408,165	$70,572,692	$64,435,936	$53,696,614
Brodalumab	$0	$8,732,750	$23,287,334	$46,574,669	$87,327,504
Total annual biologic drug cost to commercial pharmacy health plan	$414,362,647	$410,664,518	$404,500,969	$394,639,292	$377,381,357

Gu T, Shah N, Deshpande G, et al. Comparing biologic cost per treated patient across indications among adult US managed care patients: a retrospective cohort study. Drugs Real World Outcomes 2016;3:369-81

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